Product Information
METFORMIN HCL 500 MG TABLET is a generic product labeled by Major Pharmaceuticals, priced at $0.0145 per EA under NDC 00904716261. Its NADAC has been published 259 times since Oct 20, 2021.
FDA first approved this application on Apr 22, 2010. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
500 mg/1
Manufacturer
Major PharmaceuticalsNDC
00904716261
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
METFORMIN HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA090564FDA Approved
4/22/2010
TE Code
AB
On Market Since
6/26/2019
Pharmacological Classes
Price Statistics
The NADAC for METFORMIN HCL 500 MG TABLET has been published 259 times since Oct 20, 2021, and over the history we have for it it has declined 11.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0145 per EA |
|---|---|
| All-time high | $0.0177 (Nov 16, 2022) |
| All-time low | $0.0123 (Nov 20, 2024) |
| 52-week high | $0.0147 |
| 52-week low | $0.0139 |
| Median price | $0.0149 |
| Average price | $0.0151 |
| Largest weekly change | +20.4% (Jun 19, 2024) |
| Weeks tracked | 259 |
| Tracking since | Oct 20, 2021 |
Generic Alternatives
The matcher finds 20 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Major Pharmaceuticals manufacturer profile
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Drug market
Metformin Hydrochloride market comparison
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Therapeutic class
Biguanide class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of METFORMIN HCL 500 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for METFORMIN HCL 500 MG TABLET, manufactured by Major Pharmaceuticals, is $0.0145 per EA (NDC 00904716261), effective Sep 30, 2026.
How has the price of METFORMIN HCL 500 MG TABLET changed over time?
Over the history we have for it, the NADAC for METFORMIN HCL 500 MG TABLET has declined 11.5%. It has been tracked across 259 weekly CMS publications since Oct 20, 2021.
What are the highest and lowest recorded NADAC prices for METFORMIN HCL 500 MG TABLET?
Since Oct 20, 2021, the NADAC for METFORMIN HCL 500 MG TABLET has ranged from a low of $0.0123 (Nov 20, 2024) to a high of $0.0177 (Nov 16, 2022), with a median of $0.0149 per EA.
Are there cheaper alternatives to METFORMIN HCL 500 MG TABLET?
20 manufacturers publish a NADAC-priced product with the same active ingredient and strength as METFORMIN HCL 500 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures METFORMIN HCL 500 MG TABLET?
METFORMIN HCL 500 MG TABLET (NDC 00904716261) is labeled by Major Pharmaceuticals, and CMS classifies it as a generic product.