Product Information
DIFLUPREDNATE 0.05% EYE DROP is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $8.9184 per ML under NDC 00378751835. Its NADAC has been published 43 times since Oct 29, 2025.
FDA first approved this application on Mar 20, 2025. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/mL
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378751835
Classification
Generic
Dosage Form
EMULSION
Route
OPHTHALMIC
Effective Date
8/19/2026
Active Ingredients
DIFLUPREDNATEApproval Type
Generic (ANDA)
FDA Application
ANDA212566FDA Approved
3/20/2025
TE Code
AB
On Market Since
9/26/2025
Price Statistics
The NADAC for DIFLUPREDNATE 0.05% EYE DROP has been published 43 times since Oct 29, 2025, and over the history we have for it it has declined 10.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $8.9184 per ML |
|---|---|
| All-time high | $10.4599 (Feb 11, 2026) |
| All-time low | $7.0479 (Jun 17, 2026) |
| 52-week high | $10.4599 |
| 52-week low | $7.0479 |
| Median price | $9.5820 |
| Average price | $9.0887 |
| Largest weekly change | +20.4% (Aug 19, 2026) |
| Weeks tracked | 43 |
| Tracking since | Oct 29, 2025 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of DIFLUPREDNATE 0.05% EYE DROP?
The current National Average Drug Acquisition Cost (NADAC) for DIFLUPREDNATE 0.05% EYE DROP, manufactured by Mylan Pharmaceuticals Inc., is $8.9184 per ML (NDC 00378751835), effective Aug 19, 2026.
How has the price of DIFLUPREDNATE 0.05% EYE DROP changed over time?
Over the history we have for it, the NADAC for DIFLUPREDNATE 0.05% EYE DROP has declined 10.2%. It has been tracked across 43 weekly CMS publications since Oct 29, 2025.
What are the highest and lowest recorded NADAC prices for DIFLUPREDNATE 0.05% EYE DROP?
Since Oct 29, 2025, the NADAC for DIFLUPREDNATE 0.05% EYE DROP has ranged from a low of $7.0479 (Jun 17, 2026) to a high of $10.4599 (Feb 11, 2026), with a median of $9.5820 per ML.
Are there cheaper alternatives to DIFLUPREDNATE 0.05% EYE DROP?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as DIFLUPREDNATE 0.05% EYE DROP in a comparable dosage form, but none are currently priced below it.
Who manufactures DIFLUPREDNATE 0.05% EYE DROP?
DIFLUPREDNATE 0.05% EYE DROP (NDC 00378751835) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.