Product Information
DIFLUPREDNATE 0.05% EYE DROP is a generic product labeled by Caplin Steriles Limited, priced at $9.6866 per ML under NDC 65145016101. Its NADAC has been published 73 times since May 14, 2025.
FDA first approved this application on Dec 13, 2024. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/mL
Manufacturer
Caplin Steriles LimitedNDC
65145016101
Classification
Generic
Dosage Form
EMULSION
Route
OPHTHALMIC
Effective Date
9/23/2026
Active Ingredients
DIFLUPREDNATEApproval Type
Generic (ANDA)
FDA Application
ANDA219441FDA Approved
12/13/2024
TE Code
AB
On Market Since
12/26/2024
Price Statistics
The NADAC for DIFLUPREDNATE 0.05% EYE DROP has been published 73 times since May 14, 2025, and over the history we have for it it has declined 28.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $9.6866 per ML |
|---|---|
| All-time high | $13.4452 (May 14, 2025) |
| All-time low | $7.0479 (Jun 17, 2026) |
| 52-week high | $10.4599 |
| 52-week low | $7.0479 |
| Median price | $9.9308 |
| Average price | $9.8841 |
| Largest weekly change | +20.4% (Aug 19, 2026) |
| Weeks tracked | 73 |
| Tracking since | May 14, 2025 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Caplin Steriles Limited manufacturer profile
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Drug market
Difluprednate market comparison
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Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of DIFLUPREDNATE 0.05% EYE DROP?
The current National Average Drug Acquisition Cost (NADAC) for DIFLUPREDNATE 0.05% EYE DROP, manufactured by Caplin Steriles Limited, is $9.6866 per ML (NDC 65145016101), effective Sep 30, 2026.
How has the price of DIFLUPREDNATE 0.05% EYE DROP changed over time?
Over the history we have for it, the NADAC for DIFLUPREDNATE 0.05% EYE DROP has declined 28.0%. It has been tracked across 73 weekly CMS publications since May 14, 2025.
What are the highest and lowest recorded NADAC prices for DIFLUPREDNATE 0.05% EYE DROP?
Since May 14, 2025, the NADAC for DIFLUPREDNATE 0.05% EYE DROP has ranged from a low of $7.0479 (Jun 17, 2026) to a high of $13.4452 (May 14, 2025), with a median of $9.9308 per ML.
Are there cheaper alternatives to DIFLUPREDNATE 0.05% EYE DROP?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as DIFLUPREDNATE 0.05% EYE DROP in a comparable dosage form, but none are currently priced below it.
Who manufactures DIFLUPREDNATE 0.05% EYE DROP?
DIFLUPREDNATE 0.05% EYE DROP (NDC 65145016101) is labeled by Caplin Steriles Limited, and CMS classifies it as a generic product.