This NDC is on FDA's drug shortage list (posted Oct 31, 2017)
Product Information
HYDROMORPHONE 500 MG/50 ML VIAL is a generic product labeled by Hospira Inc., priced at $2.5663 per ML under NDC 00409263450. Its NADAC has been published 36 times since Jan 22, 2014.
FDA first approved this application on Jun 17, 2008. Its Orange Book therapeutic-equivalence code is AP.
Strength
10 mg/mL
Manufacturer
Hospira Inc.NDC
00409263450
Classification
Generic
Dosage Form
INJECTION, SOLUTION
Route
INTRAMUSCULAR; INTRAVENOUS; SUBCUTANEOUS
Effective Date
5/20/2026
Active Ingredients
HYDROMORPHONE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA078591FDA Approved
6/17/2008
TE Code
AP
On Market Since
7/31/2008
Pharmacological Classes
Price Statistics
The NADAC for HYDROMORPHONE 500 MG/50 ML VIAL has been published 36 times since Jan 22, 2014, and over the history we have for it it has risen 40.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.5663 per ML |
|---|---|
| All-time high | $2.5663 (Aug 19, 2026) |
| All-time low | $1.8255 (Jan 22, 2014) |
| 52-week high | $2.5663 |
| 52-week low | $2.4402 |
| Median price | $2.5453 |
| Average price | $2.4365 |
| Largest weekly change | +33.7% (Jan 21, 2026) |
| Weeks tracked | 36 |
| Tracking since | Jan 22, 2014 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of HYDROMORPHONE 500 MG/50 ML VIAL?
The current National Average Drug Acquisition Cost (NADAC) for HYDROMORPHONE 500 MG/50 ML VIAL, manufactured by Hospira Inc., is $2.5663 per ML (NDC 00409263450), effective Aug 19, 2026.
How has the price of HYDROMORPHONE 500 MG/50 ML VIAL changed over time?
Over the history we have for it, the NADAC for HYDROMORPHONE 500 MG/50 ML VIAL has risen 40.6%. It has been tracked across 36 weekly CMS publications since Jan 22, 2014.
What are the highest and lowest recorded NADAC prices for HYDROMORPHONE 500 MG/50 ML VIAL?
Since Jan 22, 2014, the NADAC for HYDROMORPHONE 500 MG/50 ML VIAL has ranged from a low of $1.8255 (Jan 22, 2014) to a high of $2.5663 (Aug 19, 2026), with a median of $2.5453 per ML.
Are there cheaper alternatives to HYDROMORPHONE 500 MG/50 ML VIAL?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as HYDROMORPHONE 500 MG/50 ML VIAL in a comparable dosage form, but none are currently priced below it.
Who manufactures HYDROMORPHONE 500 MG/50 ML VIAL?
HYDROMORPHONE 500 MG/50 ML VIAL (NDC 00409263450) is labeled by Hospira Inc., and CMS classifies it as a generic product.
Is HYDROMORPHONE 500 MG/50 ML VIAL in shortage?
Yes — NDC 00409263450 is currently listed in FDA's drug shortage database (posted Oct 31, 2017).