Product Information
TRAMADOL HCL 50 MG TABLET is a generic product labeled by Major Pharmaceuticals, priced at $0.0248 per EA under NDC 00904749661. Its NADAC has been published 84 times since Feb 26, 2025.
FDA first approved this application on Jun 20, 2002. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
50 mg/1
Manufacturer
Major PharmaceuticalsNDC
00904749661
Classification
Generic
Dosage Form
TABLET, COATED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
TRAMADOL HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA076003FDA Approved
6/20/2002
TE Code
AB
On Market Since
11/22/2024
Pharmacological Classes
Price Statistics
The NADAC for TRAMADOL HCL 50 MG TABLET has been published 84 times since Feb 26, 2025, and over the history we have for it it has held within roughly two percent of its current level. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0248 per EA |
|---|---|
| All-time high | $0.0260 (May 14, 2025) |
| All-time low | $0.0235 (Jul 22, 2026) |
| 52-week high | $0.0251 |
| 52-week low | $0.0235 |
| Median price | $0.0244 |
| Average price | $0.0245 |
| Largest weekly change | +4.9% (Mar 19, 2025) |
| Weeks tracked | 84 |
| Tracking since | Feb 26, 2025 |
Generic Alternatives
The matcher finds 8 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 4% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Major Pharmaceuticals manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Tramadol Hydrochloride market comparison
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Therapeutic class
Opioid Agonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of TRAMADOL HCL 50 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for TRAMADOL HCL 50 MG TABLET, manufactured by Major Pharmaceuticals, is $0.0248 per EA (NDC 00904749661), effective Sep 30, 2026.
How has the price of TRAMADOL HCL 50 MG TABLET changed over time?
Over the history we have for it, the NADAC for TRAMADOL HCL 50 MG TABLET has held within roughly two percent of its current level. It has been tracked across 84 weekly CMS publications since Feb 26, 2025.
What are the highest and lowest recorded NADAC prices for TRAMADOL HCL 50 MG TABLET?
Since Feb 26, 2025, the NADAC for TRAMADOL HCL 50 MG TABLET has ranged from a low of $0.0235 (Jul 22, 2026) to a high of $0.0260 (May 14, 2025), with a median of $0.0244 per EA.
Are there cheaper alternatives to TRAMADOL HCL 50 MG TABLET?
Yes. 8 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, TRAMADOL HCL 50 MG TABLET, is $0.0239 per EA — about 4% below TRAMADOL HCL 50 MG TABLET.
Who manufactures TRAMADOL HCL 50 MG TABLET?
TRAMADOL HCL 50 MG TABLET (NDC 00904749661) is labeled by Major Pharmaceuticals, and CMS classifies it as a generic product.