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Product Information

ASTAGRAF XL 5 MG CAPSULE is a brand product labeled by Astellas Pharma US, Inc., priced at $27.7722 per EA under NDC 00469068773. Its NADAC has been published 74 times since Aug 21, 2024.

FDA first approved this application on Jul 19, 2013. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.

ASTAGRAF XL 5 MG CAPSULE

tacrolimus extended-release capsules
$27.7722per EA

Strength

5 mg/1

NDC

00469068773

Classification

Brand

Dosage Form

CAPSULE, COATED, EXTENDED RELEASE

Route

ORAL

Effective Date

1/13/2025

Active Ingredients

TACROLIMUS

Approval Type

New Drug (NDA)

FDA Application

NDA204096

FDA Approved

7/19/2013

TE Code

AB

On Market Since

7/19/2013

Pharmacological Classes

Calcineurin Inhibitor Immunosuppressant
Calcineurin Inhibitors

Price Statistics

The NADAC for ASTAGRAF XL 5 MG CAPSULE has been published 74 times since Aug 21, 2024, and over the history we have for it it has risen 3.6%. The table below summarizes its recorded NADAC range and movement.

Current price$27.7722 per EA
All-time high$27.7722 (Jan 14, 2026)
All-time low$26.8105 (Aug 21, 2024)
52-week high$27.7722
52-week low$27.7722
Median price$27.7722
Average price$27.5133
Largest weekly change+3.0% (Jan 22, 2025)
Weeks tracked74
Tracking sinceAug 21, 2024

Price History

1W

N/A

1M

N/A

3M

N/A

6M

N/A

1Y

0.0%

3Y

N/A

5Y

N/A

All

+3.6%

Last surveyed Jan 14, 2026 — this NDC no longer appears in the current weekly NADAC file.

Generic Alternatives

No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the tacrolimus extended-release capsules market page.

Lowest-Cost Alternatives

No alternatives available

No alternatives found with the same active ingredient and strength in a comparable dosage form.

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$10.3142
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RESTASIS 0.05% EYE EMULSION
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$10.3166
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Frequently asked questions

What is the NADAC price of ASTAGRAF XL 5 MG CAPSULE?

The current National Average Drug Acquisition Cost (NADAC) for ASTAGRAF XL 5 MG CAPSULE, manufactured by Astellas Pharma US, Inc., is $27.7722 per EA (NDC 00469068773), effective Jan 14, 2026.

How has the price of ASTAGRAF XL 5 MG CAPSULE changed over time?

Over the history we have for it, the NADAC for ASTAGRAF XL 5 MG CAPSULE has risen 3.6%. It has been tracked across 74 weekly CMS publications since Aug 21, 2024.

What are the highest and lowest recorded NADAC prices for ASTAGRAF XL 5 MG CAPSULE?

Since Aug 21, 2024, the NADAC for ASTAGRAF XL 5 MG CAPSULE has ranged from a low of $26.8105 (Aug 21, 2024) to a high of $27.7722 (Jan 14, 2026), with a median of $27.7722 per EA.

Are there cheaper alternatives to ASTAGRAF XL 5 MG CAPSULE?

No other NADAC-published product currently shares the active ingredient and strength of ASTAGRAF XL 5 MG CAPSULE in a comparable dosage form, so no direct lower-cost alternative is listed.

Who manufactures ASTAGRAF XL 5 MG CAPSULE?

ASTAGRAF XL 5 MG CAPSULE (NDC 00469068773) is labeled by Astellas Pharma US, Inc., and CMS classifies it as a brand product.