Product Information
PROGRAF 0.5 MG CAPSULE is a brand product labeled by Astellas Pharma US, Inc., priced at $3.6645 per EA under NDC 00469060773. Its NADAC has been published 657 times since Nov 28, 2013.
The High Outlier badge above means this manufacturer's average price in the Tacrolimus market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
.5 mg/1
Manufacturer
Astellas Pharma US, Inc.NDC
00469060773
Classification
Brand
Dosage Form
CAPSULE, GELATIN COATED
Route
ORAL
Last Updated
6/17/2026
Active Ingredients
TACROLIMUSApproval Type
New Drug (NDA)
FDA Application
NDA050708On Market Since
8/24/1998
Pharmacological Classes
Price Statistics
The NADAC for PROGRAF 0.5 MG CAPSULE has been published 657 times since Nov 28, 2013, and over the history we have for it it has risen 92.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $3.6645 per EA |
|---|---|
| All-time high | $3.6717 (Jun 10, 2026) |
| All-time low | $1.9033 (Nov 28, 2013) |
| 52-week high | $3.6717 |
| 52-week low | $3.5640 |
| Median price | $2.9124 |
| Average price | $2.8969 |
| Largest weekly change | +9.9% (Apr 22, 2015) |
| Weeks tracked | 657 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 12 NADAC-published products sharing this drug's active ingredient, strength, and dosage form across 10 manufacturers (up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 96% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of PROGRAF 0.5 MG CAPSULE?
The current National Average Drug Acquisition Cost (NADAC) for PROGRAF 0.5 MG CAPSULE, manufactured by Astellas Pharma US, Inc., is $3.6645 per EA (NDC 00469060773), effective Jun 24, 2026.
How has the price of PROGRAF 0.5 MG CAPSULE changed over time?
Over the history we have for it, the NADAC for PROGRAF 0.5 MG CAPSULE has risen 92.5%. It has been tracked across 657 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for PROGRAF 0.5 MG CAPSULE?
Since Nov 28, 2013, the NADAC for PROGRAF 0.5 MG CAPSULE has ranged from a low of $1.9033 (Nov 28, 2013) to a high of $3.6717 (Jun 10, 2026), with a median of $2.9124 per EA.
Are there cheaper alternatives to PROGRAF 0.5 MG CAPSULE?
Yes. 12 NADAC-published products share the same active ingredient, strength, and dosage form. The lowest-priced option, TACROLIMUS 0.5 MG CAPSULE (IMMEDIATE RELEASE), is $0.1327 per EA — about 96% below PROGRAF 0.5 MG CAPSULE.
Who manufactures PROGRAF 0.5 MG CAPSULE?
PROGRAF 0.5 MG CAPSULE (NDC 00469060773) is labeled by Astellas Pharma US, Inc., and CMS classifies it as a brand product.
Related Drugs
Same classification