Product Information
PROGRAF 0.5 MG CAPSULE is a brand product labeled by Astellas Pharma US, Inc., priced at $3.6591 per EA under NDC 00469060773. Its NADAC has been published 671 times since Nov 28, 2013.
FDA first approved this application on Apr 8, 1994. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The High Outlier badge above means this manufacturer's average price in the Tacrolimus market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
.5 mg/1
Manufacturer
Astellas Pharma US, Inc.NDC
00469060773
Classification
Brand
Dosage Form
CAPSULE, GELATIN COATED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
TACROLIMUSApproval Type
New Drug (NDA)
FDA Application
NDA050708FDA Approved
4/8/1994
TE Code
AB
On Market Since
8/24/1998
Pharmacological Classes
Price Statistics
The NADAC for PROGRAF 0.5 MG CAPSULE has been published 671 times since Nov 28, 2013, and over the history we have for it it has risen 92.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $3.6591 per EA |
|---|---|
| All-time high | $3.6717 (Jun 10, 2026) |
| All-time low | $1.9033 (Nov 28, 2013) |
| 52-week high | $3.6717 |
| 52-week low | $3.5640 |
| Median price | $2.9256 |
| Average price | $2.9128 |
| Largest weekly change | +9.9% (Apr 22, 2015) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 12 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 97% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Astellas Pharma US, Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Tacrolimus market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Calcineurin Inhibitor Immunosuppressant class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of PROGRAF 0.5 MG CAPSULE?
The current National Average Drug Acquisition Cost (NADAC) for PROGRAF 0.5 MG CAPSULE, manufactured by Astellas Pharma US, Inc., is $3.6591 per EA (NDC 00469060773), effective Sep 30, 2026.
How has the price of PROGRAF 0.5 MG CAPSULE changed over time?
Over the history we have for it, the NADAC for PROGRAF 0.5 MG CAPSULE has risen 92.3%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for PROGRAF 0.5 MG CAPSULE?
Since Nov 28, 2013, the NADAC for PROGRAF 0.5 MG CAPSULE has ranged from a low of $1.9033 (Nov 28, 2013) to a high of $3.6717 (Jun 10, 2026), with a median of $2.9256 per EA.
Are there cheaper alternatives to PROGRAF 0.5 MG CAPSULE?
Yes. 12 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, TACROLIMUS 0.5 MG CAPSULE (IMMEDIATE RELEASE), is $0.1227 per EA — about 97% below PROGRAF 0.5 MG CAPSULE.
Who manufactures PROGRAF 0.5 MG CAPSULE?
PROGRAF 0.5 MG CAPSULE (NDC 00469060773) is labeled by Astellas Pharma US, Inc., and CMS classifies it as a brand product.