Product Information
DOXYCYCLINE HYC DR 50 MG TAB is a generic product labeled by Actavis Pharma, Inc., priced at $1.5694 per EA under NDC 00591455022. Its NADAC has been published 175 times since May 19, 2021.
FDA first approved this application on Dec 14, 2011. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
50 mg/1
Manufacturer
Actavis Pharma, Inc.NDC
00591455022
Classification
Generic
Dosage Form
TABLET, DELAYED RELEASE
Route
ORAL
Effective Date
4/22/2026
Active Ingredients
DOXYCYCLINE HYCLATEApproval Type
Generic (ANDA)
FDA Application
ANDA090134FDA Approved
12/14/2011
TE Code
AB
On Market Since
8/14/2019
Pharmacological Classes
Price Statistics
The NADAC for DOXYCYCLINE HYC DR 50 MG TAB has been published 175 times since May 19, 2021, and over the history we have for it it has declined 78.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.5694 per EA |
|---|---|
| All-time high | $7.1248 (May 11, 2022) |
| All-time low | $1.3741 (Dec 17, 2025) |
| 52-week high | $2.4192 |
| 52-week low | $1.3741 |
| Median price | $2.4192 |
| Average price | $3.7069 |
| Largest weekly change | -53.1% (Apr 17, 2024) |
| Weeks tracked | 175 |
| Tracking since | May 19, 2021 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of DOXYCYCLINE HYC DR 50 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for DOXYCYCLINE HYC DR 50 MG TAB, manufactured by Actavis Pharma, Inc., is $1.5694 per EA (NDC 00591455022), effective Aug 19, 2026.
How has the price of DOXYCYCLINE HYC DR 50 MG TAB changed over time?
Over the history we have for it, the NADAC for DOXYCYCLINE HYC DR 50 MG TAB has declined 78.0%. It has been tracked across 175 weekly CMS publications since May 19, 2021.
What are the highest and lowest recorded NADAC prices for DOXYCYCLINE HYC DR 50 MG TAB?
Since May 19, 2021, the NADAC for DOXYCYCLINE HYC DR 50 MG TAB has ranged from a low of $1.3741 (Dec 17, 2025) to a high of $7.1248 (May 11, 2022), with a median of $2.4192 per EA.
Are there cheaper alternatives to DOXYCYCLINE HYC DR 50 MG TAB?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as DOXYCYCLINE HYC DR 50 MG TAB in a comparable dosage form, but none are currently priced below it.
Who manufactures DOXYCYCLINE HYC DR 50 MG TAB?
DOXYCYCLINE HYC DR 50 MG TAB (NDC 00591455022) is labeled by Actavis Pharma, Inc., and CMS classifies it as a generic product.