Drug Markets/Doxycycline Hyclate

Doxycycline Hyclate

87 NDCs across 20 manufacturers|85 Generic,2 Brand

Doxycycline Hyclate is used to treat anthrax, campylobacter infections, cholera, granuloma inguinale, mycoplasma infections and plague, per the National Library of Medicine's MED-RT classification.

▸ More about this market

The brand product was first FDA-approved before 1982, and the first generic was approved Jan 1, 1982. FDA's Orange Book lists 64 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $82 million on Doxycycline Hyclate across 6.7 million claims for 4.6 million beneficiaries.

Doxycycline Hyclate is available as 87 NDCs from 20 manufacturers (85 generic, 2 brand), with NADAC prices from $0.10 to $18.18 per EA — the most expensive product costs about 185× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.

Total NDCs

85G / 2B

Manufacturers

competing in market

Price Spread

$0.10 – $18.18

per EA

7d Activity

16↑50↓21 flat

avg -0.6% WoW · of 87 NDCs

Market Price Trend

Monthly average NADAC per unit, split by generic and brand.

Manufacturer Breakdown

20 manufacturers producing DOXYCYCLINE HYCLATE(3 pricing outliers)

Alembic Pharmaceuticals Inc.

10 NDCs

$1.3781

avg/unit

Sun Pharmaceutical Industries Inc.

8 NDCs

$0.1203

avg/unit

PuraCap Laboratories LLC

8 NDCs

$0.1129

avg/unit

Hikma Pharmaceuticals USA Inc.

5 NDCs

$0.1167

avg/unit

Viona Pharmaceuticals Inc.

5 NDCs

$0.1167

avg/unit

Major Pharmaceuticals

5 NDCs

$0.1097

avg/unit

Heritage Pharmaceuticals Inc.

Solco Healthcare US LLC

Lupin Pharmaceuticals Inc.

Ajanta Pharma USA Inc.

2 NDCs

$0.5518

avg/unit

Cranbury Pharmaceuticals, LLC

2 NDCs

$0.1129

avg/unit

American Health Packaging

2 NDCs

$0.1089

avg/unit

Larken Laboratories, Inc.

Acella Pharmaceuticals, LLC

1 NDC

$0.1129

avg/unit

Drug Portfolio

87 NDCs total, 87 shown

Drug ↕	NDC	Manufacturer ↕	Price	Market Outlier	Class	7d Change ↕	Therapeutic Class
DORYX MPC DR 60 MG TABLET	51862056012	Mayne Pharma	$18.1822 per EA	High Outlier	Brand	—	Tetracycline-class Drug
DORYX MPC DR 60 MG TABLET	51862056060	Mayne Pharma	$18.1822 per EA	High Outlier	Brand	—	Tetracycline-class Drug
DOXYCYCLINE 50 MG TABLET	72143021160	JG Pharma Inc.	$7.8552 per EA	High Outlier	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYC DR 75 MG TAB	23155014101	Heritage Pharmaceuticals Inc.	$6.6577 per EA	High Outlier	Generic	—	Tetracycline-class Drug
DOXYCYCLINE 50 MG TABLET	62332049960	Alembic Pharmaceuticals Inc.	$5.1581 per EA	—	Generic	-4.85%	Tetracycline-class Drug
DOXYCYCLINE 50 MG TABLET	62135062560	Chartwell RX LLC	$5.1581 per EA	—	Generic	-4.85%	Tetracycline-class Drug
DOXYCYCLINE HYC DR 200 MG TAB	62332048460	Alembic Pharmaceuticals Inc.	$3.7008 per EA	—	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYC DR 200 MG TAB	00591457560	Actavis Pharma, Inc.	$3.7008 per EA	—	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYC DR 200 MG TAB	68308071630	Mayne Pharma	$3.7008 per EA	High Outlier	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYC DR 200 MG TAB	43547032506	Solco Healthcare US LLC	$3.7008 per EA	—	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYC DR 200 MG TAB	23155061106	Heritage Pharmaceuticals Inc.	$3.7008 per EA	High Outlier	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYC DR 100 MG TAB	23155014201	Heritage Pharmaceuticals Inc.	$2.2315 per EA	High Outlier	Generic	-0.91%	Tetracycline-class Drug
DOXYCYCLINE HYC DR 100 MG TAB	62332048231	Alembic Pharmaceuticals Inc.	$2.2315 per EA	—	Generic	-0.91%	Tetracycline-class Drug
DOXYCYCLINE HYC DR 50 MG TAB	00591455022	Actavis Pharma, Inc.	$1.5694 per EA	—	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYC DR 50 MG TAB	43547046212	Solco Healthcare US LLC	$1.5694 per EA	—	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYC DR 150 MG TAB	23155014301	Heritage Pharmaceuticals Inc.	$1.1307 per EA	High Outlier	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYC DR 150 MG TAB	62332048331	Alembic Pharmaceuticals Inc.	$1.1307 per EA	—	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYC DR 150 MG TAB	43547032410	Solco Healthcare US LLC	$1.1307 per EA	—	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 150 MG TAB	62135090820	Chartwell RX LLC	$0.7220 per EA	—	Generic	+1.83%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 150 MG TAB	27241015402	Ajanta Pharma USA Inc.	$0.7220 per EA	—	Generic	+1.83%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 150 MG TAB	62332038860	Alembic Pharmaceuticals Inc.	$0.7220 per EA	—	Generic	+1.83%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 75 MG TAB	62332038760	Alembic Pharmaceuticals Inc.	$0.3816 per EA	—	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 75 MG TAB	62135090720	Chartwell RX LLC	$0.3816 per EA	—	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 75 MG TAB	27241015302	Ajanta Pharma USA Inc.	$0.3816 per EA	—	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 50 MG CAP	53489011805	Sun Pharmaceutical Industries Inc.	$0.1680 per EA	—	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 50 MG CAP	00143980250	Hikma Pharmaceuticals USA Inc.	$0.1478 per EA	—	Generic	+4.61%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 50 MG CAP	53489011802	Sun Pharmaceutical Industries Inc.	$0.1478 per EA	—	Generic	+4.61%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 50 MG CAP	72578005418	Viona Pharmaceuticals Inc.	$0.1478 per EA	—	Generic	+4.61%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 50 MG CAP	62135098450	Chartwell RX LLC	$0.1478 per EA	—	Generic	+4.61%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 50 MG CAP	62135098405	Chartwell RX LLC	$0.1478 per EA	—	Generic	+4.61%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 50 MG CAP	50268027715	AvPAK	$0.1478 per EA	—	Generic	+4.61%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 50 MG CAP	62332036250	Alembic Pharmaceuticals Inc.	$0.1478 per EA	—	Generic	+4.61%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	43386079405	Lupin Pharmaceuticals Inc.	$0.1411 per EA	—	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	43386079401	Lupin Pharmaceuticals Inc.	$0.1411 per EA	—	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	43386079450	Lupin Pharmaceuticals Inc.	$0.1411 per EA	—	Generic	—	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	24658031030	PuraCap Laboratories LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	00143211250	Hikma Pharmaceuticals USA Inc.	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	00591555305	Actavis Pharma, Inc.	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	00591555350	Actavis Pharma, Inc.	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	00904043004	Major Pharmaceuticals	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	00904043006	Major Pharmaceuticals	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	00904043095	Major Pharmaceuticals	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	24658031001	PuraCap Laboratories LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	24658031005	PuraCap Laboratories LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	24658031007	PuraCap Laboratories LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	24658031008	PuraCap Laboratories LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	24658031010	PuraCap Laboratories LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	24658031020	PuraCap Laboratories LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	24658031021	PuraCap Laboratories LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	00143211205	Hikma Pharmaceuticals USA Inc.	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	27808023401	Cranbury Pharmaceuticals, LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	27808023402	Cranbury Pharmaceuticals, LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	42192050105	Acella Pharmaceuticals, LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	42806031005	Epic Pharma LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	42806031050	Epic Pharma LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	50268027915	AvPAK	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	53489012002	Sun Pharmaceutical Industries Inc.	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	53489012005	Sun Pharmaceutical Industries Inc.	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	53489012060	Sun Pharmaceutical Industries Inc.	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	62135062601	Chartwell RX LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	62135062605	Chartwell RX LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	62135062610	Chartwell RX LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	62135062650	Chartwell RX LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	62135062696	Chartwell RX LLC	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	62584069321	American Health Packaging	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	72578000105	Viona Pharmaceuticals Inc.	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG TAB	72578000118	Viona Pharmaceuticals Inc.	$0.1129 per EA	—	Generic	-1.30%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG CAP	00143980305	Hikma Pharmaceuticals USA Inc.	$0.1049 per EA	—	Generic	-3.45%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG CAP	72578005505	Viona Pharmaceuticals Inc.	$0.1049 per EA	—	Generic	-3.45%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG CAP	53489011902	Sun Pharmaceutical Industries Inc.	$0.1049 per EA	—	Generic	-3.45%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG CAP	50268027815	AvPAK	$0.1049 per EA	—	Generic	-3.45%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG CAP	00904042806	Major Pharmaceuticals	$0.1049 per EA	—	Generic	-3.45%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG CAP	00904042804	Major Pharmaceuticals	$0.1049 per EA	—	Generic	-3.45%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG CAP	00143980350	Hikma Pharmaceuticals USA Inc.	$0.1049 per EA	—	Generic	-3.45%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG CAP	72578005518	Viona Pharmaceuticals Inc.	$0.1049 per EA	—	Generic	-3.45%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG CAP	62332036371	Alembic Pharmaceuticals Inc.	$0.1049 per EA	—	Generic	-3.45%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG CAP	62332036350	Alembic Pharmaceuticals Inc.	$0.1049 per EA	—	Generic	-3.45%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG CAP	62135098550	Chartwell RX LLC	$0.1049 per EA	—	Generic	-3.45%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG CAP	62135098505	Chartwell RX LLC	$0.1049 per EA	—	Generic	-3.45%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG CAP	60687051365	American Health Packaging	$0.1049 per EA	—	Generic	-3.45%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 100 MG CAP	53489011905	Sun Pharmaceutical Industries Inc.	$0.1049 per EA	—	Generic	-3.45%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 20 MG TAB	68047071460	Larken Laboratories, Inc.	$0.0984 per EA	—	Generic	+4.33%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 20 MG TAB	68047071401	Larken Laboratories, Inc.	$0.0984 per EA	—	Generic	+4.33%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 20 MG TAB	53489064701	Sun Pharmaceutical Industries Inc.	$0.0984 per EA	—	Generic	+4.33%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 20 MG TAB	62135062390	Chartwell RX LLC	$0.0984 per EA	—	Generic	+4.33%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 20 MG TAB	62332035231	Alembic Pharmaceuticals Inc.	$0.0984 per EA	—	Generic	+4.33%	Tetracycline-class Drug
DOXYCYCLINE HYCLATE 20 MG TAB	42806036201	Epic Pharma LLC	$0.0984 per EA	—	Generic	+4.33%	Tetracycline-class Drug

Frequently Asked Questions

What is Doxycycline Hyclate used to treat?

Doxycycline Hyclate is used to treat anthrax, campylobacter infections, cholera, granuloma inguinale, mycoplasma infections and plague, per the National Library of Medicine's MED-RT classification.

When did Doxycycline Hyclate become available as a generic?

FDA approved the first generic Doxycycline Hyclate (ANDA) on Jan 1, 1982. The Orange Book currently lists 64 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.

How much does Medicare spend on Doxycycline Hyclate?

In 2024, Medicare Part D spent $82 million on Doxycycline Hyclate across 6.7 million claims for 4.6 million beneficiaries.

How many Doxycycline Hyclate products are on the market?

The Doxycycline Hyclate drug market contains 87 NDCs from 20 manufacturers — 85 generic and 2 brand products.

What is the price range for Doxycycline Hyclate?

NADAC reference prices for Doxycycline Hyclate range from $0.0984 to $18.1822 per EA — the most expensive product costs about 185× the cheapest.

Is generic Doxycycline Hyclate cheaper than brand?

The average generic NADAC for Doxycycline Hyclate is $0.7639 per EA, versus $18.1822 for brand-labeled products — brand versions average about 24× the generic price.

Which manufacturers make Doxycycline Hyclate?

20 manufacturers list Doxycycline Hyclate in NADAC. Ranked by number of NDCs, the largest are Chartwell RX LLC (13), Alembic Pharmaceuticals Inc. (10), Sun Pharmaceutical Industries Inc. (8), PuraCap Laboratories LLC (8), Hikma Pharmaceuticals USA Inc. (5).

How has the price of Doxycycline Hyclate changed recently?

Over the past 7 days, 16 Doxycycline Hyclate NDCs rose and 50 fell, with a market-wide average change of -0.6%.