Product Information
METHYLPREDNISOLONE 400 MG/10 ML is a generic product labeled by Sandoz Inc., priced at $5.8078 per ML under NDC 00781352270. Its NADAC has been published 121 times since May 1, 2024.
FDA first approved this application on Jan 3, 2023. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
40 mg/mL
Manufacturer
Sandoz Inc.NDC
00781352270
Classification
Generic
Dosage Form
INJECTION, SUSPENSION
Route
INTRALESIONAL; INTRAMUSCULAR; INTRASYNOVIAL; SOFT TISSUE
Effective Date
4/22/2026
Active Ingredients
METHYLPREDNISOLONE ACETATEApproval Type
Generic (ANDA)
FDA Application
ANDA214870FDA Approved
1/3/2023
TE Code
AB
On Market Since
3/14/2024
Pharmacological Classes
Price Statistics
The NADAC for METHYLPREDNISOLONE 400 MG/10 ML has been published 121 times since May 1, 2024, and over the history we have for it it has risen 2.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $5.8078 per ML |
|---|---|
| All-time high | $6.5080 (Sep 10, 2025) |
| All-time low | $5.3134 (Jun 19, 2024) |
| 52-week high | $6.5080 |
| 52-week low | $5.7137 |
| Median price | $5.8749 |
| Average price | $5.9549 |
| Largest weekly change | -12.2% (Sep 17, 2025) |
| Weeks tracked | 121 |
| Tracking since | May 1, 2024 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of METHYLPREDNISOLONE 400 MG/10 ML?
The current National Average Drug Acquisition Cost (NADAC) for METHYLPREDNISOLONE 400 MG/10 ML, manufactured by Sandoz Inc., is $5.8078 per ML (NDC 00781352270), effective Aug 19, 2026.
How has the price of METHYLPREDNISOLONE 400 MG/10 ML changed over time?
Over the history we have for it, the NADAC for METHYLPREDNISOLONE 400 MG/10 ML has risen 2.5%. It has been tracked across 121 weekly CMS publications since May 1, 2024.
What are the highest and lowest recorded NADAC prices for METHYLPREDNISOLONE 400 MG/10 ML?
Since May 1, 2024, the NADAC for METHYLPREDNISOLONE 400 MG/10 ML has ranged from a low of $5.3134 (Jun 19, 2024) to a high of $6.5080 (Sep 10, 2025), with a median of $5.8749 per ML.
Are there cheaper alternatives to METHYLPREDNISOLONE 400 MG/10 ML?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as METHYLPREDNISOLONE 400 MG/10 ML in a comparable dosage form, but none are currently priced below it.
Who manufactures METHYLPREDNISOLONE 400 MG/10 ML?
METHYLPREDNISOLONE 400 MG/10 ML (NDC 00781352270) is labeled by Sandoz Inc., and CMS classifies it as a generic product.