Product Information
HYDROXYZINE HCL 25 MG TABLET is a generic product labeled by Major Pharmaceuticals, priced at $0.0342 per EA under NDC 00904661761. Its NADAC has been published 424 times since Jul 25, 2018.
FDA first approved this application on Dec 28, 2004. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25 mg/1
Manufacturer
Major PharmaceuticalsNDC
00904661761
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
HYDROXYZINE DIHYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA040604FDA Approved
12/28/2004
TE Code
AB
On Market Since
3/31/2015
Pharmacological Classes
Price Statistics
The NADAC for HYDROXYZINE HCL 25 MG TABLET has been published 424 times since Jul 25, 2018, and over the history we have for it it has declined 44.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0342 per EA |
|---|---|
| All-time high | $0.0778 (Jun 16, 2021) |
| All-time low | $0.0341 (Nov 20, 2024) |
| 52-week high | $0.0368 |
| 52-week low | $0.0342 |
| Median price | $0.0511 |
| Average price | $0.0514 |
| Largest weekly change | +60.2% (Jan 19, 2022) |
| Weeks tracked | 424 |
| Tracking since | Jul 25, 2018 |
1W
N/A
1M
N/A
3M
-4.0%
6M
-1.4%
1Y
-7.1%
3Y
-22.0%
5Y
-50.2%
All
-44.4%
Last surveyed Sep 2, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 6 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 5% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Major Pharmaceuticals manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Hydroxyzine Hydrochloride market comparison
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Therapeutic class
Antihistamine class view
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Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of HYDROXYZINE HCL 25 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for HYDROXYZINE HCL 25 MG TABLET, manufactured by Major Pharmaceuticals, is $0.0342 per EA (NDC 00904661761), effective Sep 2, 2026.
How has the price of HYDROXYZINE HCL 25 MG TABLET changed over time?
Over the history we have for it, the NADAC for HYDROXYZINE HCL 25 MG TABLET has declined 44.4%. It has been tracked across 424 weekly CMS publications since Jul 25, 2018.
What are the highest and lowest recorded NADAC prices for HYDROXYZINE HCL 25 MG TABLET?
Since Jul 25, 2018, the NADAC for HYDROXYZINE HCL 25 MG TABLET has ranged from a low of $0.0341 (Nov 20, 2024) to a high of $0.0778 (Jun 16, 2021), with a median of $0.0511 per EA.
Are there cheaper alternatives to HYDROXYZINE HCL 25 MG TABLET?
Yes. 6 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, HYDROXYZINE HCL 25 MG TABLET, is $0.0326 per EA — about 5% below HYDROXYZINE HCL 25 MG TABLET.
Who manufactures HYDROXYZINE HCL 25 MG TABLET?
HYDROXYZINE HCL 25 MG TABLET (NDC 00904661761) is labeled by Major Pharmaceuticals, and CMS classifies it as a generic product.