Product Information
ACETAMINOPHEN ER 650 MG CAPLET is a generic product labeled by Major Pharmaceuticals, priced at $0.0631 per EA under NDC 00904688365. Its NADAC has been published 215 times since Mar 4, 2020.
FDA first approved this application on Feb 25, 2000.
Strength
650 mg/1
Manufacturer
Major PharmaceuticalsNDC
00904688365
Classification
Generic
Dosage Form
TABLET, FILM COATED, EXTENDED RELEASE
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
ACETAMINOPHENApproval Type
Generic (ANDA)
FDA Application
ANDA075077FDA Approved
2/25/2000
On Market Since
3/4/2019
Price Statistics
The NADAC for ACETAMINOPHEN ER 650 MG CAPLET has been published 215 times since Mar 4, 2020, and over the history we have for it it has risen 8.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0631 per EA |
|---|---|
| All-time high | $0.0759 (Mar 15, 2023) |
| All-time low | $0.0580 (Mar 4, 2020) |
| 52-week high | $0.0631 |
| 52-week low | $0.0631 |
| Median price | $0.0669 |
| Average price | $0.0659 |
| Largest weekly change | +16.2% (Feb 22, 2023) |
| Weeks tracked | 215 |
| Tracking since | Mar 4, 2020 |
Generic Alternatives
The matcher finds 7 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 5% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Major Pharmaceuticals manufacturer profile
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Drug market
Acetaminophen market comparison
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ACETAMINOPHEN ER 650 MG CAPLET?
The current National Average Drug Acquisition Cost (NADAC) for ACETAMINOPHEN ER 650 MG CAPLET, manufactured by Major Pharmaceuticals, is $0.0631 per EA (NDC 00904688365), effective Sep 30, 2026.
How has the price of ACETAMINOPHEN ER 650 MG CAPLET changed over time?
Over the history we have for it, the NADAC for ACETAMINOPHEN ER 650 MG CAPLET has risen 8.7%. It has been tracked across 215 weekly CMS publications since Mar 4, 2020.
What are the highest and lowest recorded NADAC prices for ACETAMINOPHEN ER 650 MG CAPLET?
Since Mar 4, 2020, the NADAC for ACETAMINOPHEN ER 650 MG CAPLET has ranged from a low of $0.0580 (Mar 4, 2020) to a high of $0.0759 (Mar 15, 2023), with a median of $0.0669 per EA.
Are there cheaper alternatives to ACETAMINOPHEN ER 650 MG CAPLET?
Yes. 7 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, ARTHRITIS PAIN ER 650 MG CAPLT, is $0.0599 per EA — about 5% below ACETAMINOPHEN ER 650 MG CAPLET.
Who manufactures ACETAMINOPHEN ER 650 MG CAPLET?
ACETAMINOPHEN ER 650 MG CAPLET (NDC 00904688365) is labeled by Major Pharmaceuticals, and CMS classifies it as a generic product.