Product Information
UREA 40% CREAM is a generic product labeled by Major Pharmaceuticals, priced at $1.0750 per GM under NDC 00904716723. Its NADAC has been published 103 times since Dec 15, 2021.
Strength
400 mg/g
Manufacturer
Major PharmaceuticalsNDC
00904716723
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
10/22/2025
Active Ingredients
UREAApproval Type
Unapproved
On Market Since
7/6/2021
Price Statistics
The NADAC for UREA 40% CREAM has been published 103 times since Dec 15, 2021, and over the history we have for it it has declined 22.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.0750 per GM |
|---|---|
| All-time high | $1.3822 (May 11, 2022) |
| All-time low | $1.0097 (May 22, 2024) |
| 52-week high | $1.0750 |
| 52-week low | $1.0551 |
| Median price | $1.0551 |
| Average price | $1.1264 |
| Largest weekly change | -15.7% (May 22, 2024) |
| Weeks tracked | 103 |
| Tracking since | Dec 15, 2021 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
+1.9%
3Y
-22.2%
5Y
N/A
All
-22.2%
Last surveyed Oct 29, 2025 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 86% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Major Pharmaceuticals manufacturer profile
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Drug market
Urea market comparison
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Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of UREA 40% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for UREA 40% CREAM, manufactured by Major Pharmaceuticals, is $1.0750 per GM (NDC 00904716723), effective Oct 29, 2025.
How has the price of UREA 40% CREAM changed over time?
Over the history we have for it, the NADAC for UREA 40% CREAM has declined 22.2%. It has been tracked across 103 weekly CMS publications since Dec 15, 2021.
What are the highest and lowest recorded NADAC prices for UREA 40% CREAM?
Since Dec 15, 2021, the NADAC for UREA 40% CREAM has ranged from a low of $1.0097 (May 22, 2024) to a high of $1.3822 (May 11, 2022), with a median of $1.0551 per GM.
Are there cheaper alternatives to UREA 40% CREAM?
Yes. 4 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, UREA 40% CREAM, is $0.1462 per GM — about 86% below UREA 40% CREAM.
Who manufactures UREA 40% CREAM?
UREA 40% CREAM (NDC 00904716723) is labeled by Major Pharmaceuticals, and CMS classifies it as a generic product.