Product Information
UREA 40% CREAM is a generic product labeled by Major Pharmaceuticals, priced at $0.2620 per GM under NDC 00904716783. Its NADAC has been published 136 times since Dec 15, 2021.
Strength
400 mg/g
Manufacturer
Major PharmaceuticalsNDC
00904716783
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
1/21/2026
Active Ingredients
UREAApproval Type
Unapproved
On Market Since
7/6/2021
Price Statistics
The NADAC for UREA 40% CREAM has been published 136 times since Dec 15, 2021, and over the history we have for it it has declined 65.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.2620 per GM |
|---|---|
| All-time high | $0.7690 (Sep 14, 2022) |
| All-time low | $0.2607 (Dec 17, 2025) |
| 52-week high | $0.3004 |
| 52-week low | $0.2607 |
| Median price | $0.3891 |
| Average price | $0.4784 |
| Largest weekly change | -43.2% (Apr 17, 2024) |
| Weeks tracked | 136 |
| Tracking since | Dec 15, 2021 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
-12.8%
3Y
-65.9%
5Y
N/A
All
-65.9%
Last surveyed Feb 11, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 44% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Major Pharmaceuticals manufacturer profile
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Drug market
Urea market comparison
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Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of UREA 40% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for UREA 40% CREAM, manufactured by Major Pharmaceuticals, is $0.2620 per GM (NDC 00904716783), effective Feb 11, 2026.
How has the price of UREA 40% CREAM changed over time?
Over the history we have for it, the NADAC for UREA 40% CREAM has declined 65.9%. It has been tracked across 136 weekly CMS publications since Dec 15, 2021.
What are the highest and lowest recorded NADAC prices for UREA 40% CREAM?
Since Dec 15, 2021, the NADAC for UREA 40% CREAM has ranged from a low of $0.2607 (Dec 17, 2025) to a high of $0.7690 (Sep 14, 2022), with a median of $0.3891 per GM.
Are there cheaper alternatives to UREA 40% CREAM?
Yes. 4 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, UREA 40% CREAM, is $0.1462 per GM — about 44% below UREA 40% CREAM.
Who manufactures UREA 40% CREAM?
UREA 40% CREAM (NDC 00904716783) is labeled by Major Pharmaceuticals, and CMS classifies it as a generic product.