Product Information
DESONIDE 0.05% OINTMENT is a generic product labeled by Encube Ethicals, Inc., priced at $0.3921 per GM under NDC 21922000404. Its NADAC has been published 361 times since Nov 6, 2019.
FDA first approved this application on Jan 30, 2019. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922000404
Classification
Generic
Dosage Form
OINTMENT
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
DESONIDEApproval Type
Generic (ANDA)
FDA Application
ANDA210998FDA Approved
1/30/2019
TE Code
AB
On Market Since
3/20/2019
Pharmacological Classes
Price Statistics
The NADAC for DESONIDE 0.05% OINTMENT has been published 361 times since Nov 6, 2019, and over the history we have for it it has declined 72.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.3921 per GM |
|---|---|
| All-time high | $2.1282 (Feb 10, 2021) |
| All-time low | $0.3624 (Nov 20, 2024) |
| 52-week high | $0.4692 |
| 52-week low | $0.3771 |
| Median price | $0.6899 |
| Average price | $0.8709 |
| Largest weekly change | +81.9% (Dec 23, 2020) |
| Weeks tracked | 361 |
| Tracking since | Nov 6, 2019 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 35% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Encube Ethicals, Inc. manufacturer profile
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Drug market
Desonide Ointment, 0.05% market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Corticosteroid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of DESONIDE 0.05% OINTMENT?
The current National Average Drug Acquisition Cost (NADAC) for DESONIDE 0.05% OINTMENT, manufactured by Encube Ethicals, Inc., is $0.3921 per GM (NDC 21922000404), effective Sep 30, 2026.
How has the price of DESONIDE 0.05% OINTMENT changed over time?
Over the history we have for it, the NADAC for DESONIDE 0.05% OINTMENT has declined 72.5%. It has been tracked across 361 weekly CMS publications since Nov 6, 2019.
What are the highest and lowest recorded NADAC prices for DESONIDE 0.05% OINTMENT?
Since Nov 6, 2019, the NADAC for DESONIDE 0.05% OINTMENT has ranged from a low of $0.3624 (Nov 20, 2024) to a high of $2.1282 (Feb 10, 2021), with a median of $0.6899 per GM.
Are there cheaper alternatives to DESONIDE 0.05% OINTMENT?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, DESONIDE 0.05% OINTMENT, is $0.2566 per GM — about 35% below DESONIDE 0.05% OINTMENT.
Who manufactures DESONIDE 0.05% OINTMENT?
DESONIDE 0.05% OINTMENT (NDC 21922000404) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.