Product Information
CLOBETASOL 0.05% CREAM is a generic product labeled by Encube Ethicals, Inc., priced at $0.1668 per GM under NDC 21922001605. Its NADAC has been published 310 times since Oct 28, 2020.
FDA first approved this application on Aug 28, 2020. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922001605
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
CLOBETASOL PROPIONATEApproval Type
Generic (ANDA)
FDA Application
ANDA212982FDA Approved
8/28/2020
TE Code
AB1
On Market Since
10/1/2020
Pharmacological Classes
Price Statistics
The NADAC for CLOBETASOL 0.05% CREAM has been published 310 times since Oct 28, 2020, and over the history we have for it it has declined 75.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1668 per GM |
|---|---|
| All-time high | $0.8173 (Jan 13, 2021) |
| All-time low | $0.1128 (Nov 20, 2024) |
| 52-week high | $0.1780 |
| 52-week low | $0.1668 |
| Median price | $0.1952 |
| Average price | $0.3008 |
| Largest weekly change | +41.2% (Aug 21, 2024) |
| Weeks tracked | 310 |
| Tracking since | Oct 28, 2020 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 27% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Encube Ethicals, Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Clobetasol Propionate Cream USP, 0.05% market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Corticosteroid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of CLOBETASOL 0.05% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for CLOBETASOL 0.05% CREAM, manufactured by Encube Ethicals, Inc., is $0.1668 per GM (NDC 21922001605), effective Sep 30, 2026.
How has the price of CLOBETASOL 0.05% CREAM changed over time?
Over the history we have for it, the NADAC for CLOBETASOL 0.05% CREAM has declined 75.3%. It has been tracked across 310 weekly CMS publications since Oct 28, 2020.
What are the highest and lowest recorded NADAC prices for CLOBETASOL 0.05% CREAM?
Since Oct 28, 2020, the NADAC for CLOBETASOL 0.05% CREAM has ranged from a low of $0.1128 (Nov 20, 2024) to a high of $0.8173 (Jan 13, 2021), with a median of $0.1952 per GM.
Are there cheaper alternatives to CLOBETASOL 0.05% CREAM?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CLOBETASOL 0.05% CREAM, is $0.1216 per GM — about 27% below CLOBETASOL 0.05% CREAM.
Who manufactures CLOBETASOL 0.05% CREAM?
CLOBETASOL 0.05% CREAM (NDC 21922001605) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.