Product Information
CLOBETASOL 0.05% CREAM is a generic product labeled by Encube Ethicals, Inc., priced at $0.1158 per GM under NDC 21922001606. Its NADAC has been published 304 times since Oct 28, 2020.
FDA first approved this application on Aug 28, 2020. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922001606
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
CLOBETASOL PROPIONATEApproval Type
Generic (ANDA)
FDA Application
ANDA212982FDA Approved
8/28/2020
TE Code
AB1
On Market Since
10/1/2020
Pharmacological Classes
Price Statistics
The NADAC for CLOBETASOL 0.05% CREAM has been published 304 times since Oct 28, 2020, and over the history we have for it it has declined 86.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1158 per GM |
|---|---|
| All-time high | $0.8927 (Mar 10, 2021) |
| All-time low | $0.0808 (Nov 20, 2024) |
| 52-week high | $0.1526 |
| 52-week low | $0.1096 |
| Median price | $0.1755 |
| Average price | $0.2747 |
| Largest weekly change | +45.4% (Aug 21, 2024) |
| Weeks tracked | 304 |
| Tracking since | Oct 28, 2020 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of CLOBETASOL 0.05% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for CLOBETASOL 0.05% CREAM, manufactured by Encube Ethicals, Inc., is $0.1158 per GM (NDC 21922001606), effective Aug 19, 2026.
How has the price of CLOBETASOL 0.05% CREAM changed over time?
Over the history we have for it, the NADAC for CLOBETASOL 0.05% CREAM has declined 86.6%. It has been tracked across 304 weekly CMS publications since Oct 28, 2020.
What are the highest and lowest recorded NADAC prices for CLOBETASOL 0.05% CREAM?
Since Oct 28, 2020, the NADAC for CLOBETASOL 0.05% CREAM has ranged from a low of $0.0808 (Nov 20, 2024) to a high of $0.8927 (Mar 10, 2021), with a median of $0.1755 per GM.
Are there cheaper alternatives to CLOBETASOL 0.05% CREAM?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as CLOBETASOL 0.05% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures CLOBETASOL 0.05% CREAM?
CLOBETASOL 0.05% CREAM (NDC 21922001606) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.