Product Information
CLOBETASOL 0.05% OINTMENT is a generic product labeled by Encube Ethicals, Inc., priced at $0.1383 per GM under NDC 21922001704. Its NADAC has been published 348 times since Feb 5, 2020.
FDA first approved this application on Nov 15, 2019. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922001704
Classification
Generic
Dosage Form
OINTMENT
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
CLOBETASOL PROPIONATEApproval Type
Generic (ANDA)
FDA Application
ANDA211295FDA Approved
11/15/2019
TE Code
AB
On Market Since
11/18/2019
Pharmacological Classes
Price Statistics
The NADAC for CLOBETASOL 0.05% OINTMENT has been published 348 times since Feb 5, 2020, and over the history we have for it it has declined 81.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1383 per GM |
|---|---|
| All-time high | $0.8216 (Mar 11, 2020) |
| All-time low | $0.1183 (Jul 22, 2026) |
| 52-week high | $0.1644 |
| 52-week low | $0.1183 |
| Median price | $0.2717 |
| Average price | $0.3583 |
| Largest weekly change | +62.6% (Aug 21, 2024) |
| Weeks tracked | 348 |
| Tracking since | Feb 5, 2020 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 22% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Encube Ethicals, Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Clobetasol Propionate Ointment USP, 0.05% market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Corticosteroid class view
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Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of CLOBETASOL 0.05% OINTMENT?
The current National Average Drug Acquisition Cost (NADAC) for CLOBETASOL 0.05% OINTMENT, manufactured by Encube Ethicals, Inc., is $0.1383 per GM (NDC 21922001704), effective Sep 30, 2026.
How has the price of CLOBETASOL 0.05% OINTMENT changed over time?
Over the history we have for it, the NADAC for CLOBETASOL 0.05% OINTMENT has declined 81.2%. It has been tracked across 348 weekly CMS publications since Feb 5, 2020.
What are the highest and lowest recorded NADAC prices for CLOBETASOL 0.05% OINTMENT?
Since Feb 5, 2020, the NADAC for CLOBETASOL 0.05% OINTMENT has ranged from a low of $0.1183 (Jul 22, 2026) to a high of $0.8216 (Mar 11, 2020), with a median of $0.2717 per GM.
Are there cheaper alternatives to CLOBETASOL 0.05% OINTMENT?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CLOBETASOL 0.05% OINTMENT, is $0.1083 per GM — about 22% below CLOBETASOL 0.05% OINTMENT.
Who manufactures CLOBETASOL 0.05% OINTMENT?
CLOBETASOL 0.05% OINTMENT (NDC 21922001704) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.