Product Information
KETOCONAZOLE 2% CREAM is a generic product labeled by Encube Ethicals, Inc., priced at $0.2848 per GM under NDC 21922002504. Its NADAC has been published 276 times since Jun 23, 2021.
FDA first approved this application on May 20, 2021. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
20 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922002504
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
KETOCONAZOLEApproval Type
Generic (ANDA)
FDA Application
ANDA212443FDA Approved
5/20/2021
TE Code
AB
On Market Since
5/27/2021
Pharmacological Classes
Price Statistics
The NADAC for KETOCONAZOLE 2% CREAM has been published 276 times since Jun 23, 2021, and over the history we have for it it has declined 50.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.2848 per GM |
|---|---|
| All-time high | $0.6028 (Sep 15, 2021) |
| All-time low | $0.2119 (Jul 17, 2024) |
| 52-week high | $0.3514 |
| 52-week low | $0.2848 |
| Median price | $0.3107 |
| Average price | $0.3425 |
| Largest weekly change | +28.7% (Aug 21, 2024) |
| Weeks tracked | 276 |
| Tracking since | Jun 23, 2021 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 43% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Encube Ethicals, Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Ketoconazole Cream, 2% market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Azole Antifungal class view
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Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of KETOCONAZOLE 2% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for KETOCONAZOLE 2% CREAM, manufactured by Encube Ethicals, Inc., is $0.2848 per GM (NDC 21922002504), effective Sep 30, 2026.
How has the price of KETOCONAZOLE 2% CREAM changed over time?
Over the history we have for it, the NADAC for KETOCONAZOLE 2% CREAM has declined 50.0%. It has been tracked across 276 weekly CMS publications since Jun 23, 2021.
What are the highest and lowest recorded NADAC prices for KETOCONAZOLE 2% CREAM?
Since Jun 23, 2021, the NADAC for KETOCONAZOLE 2% CREAM has ranged from a low of $0.2119 (Jul 17, 2024) to a high of $0.6028 (Sep 15, 2021), with a median of $0.3107 per GM.
Are there cheaper alternatives to KETOCONAZOLE 2% CREAM?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, KETOCONAZOLE 2% CREAM, is $0.1622 per GM — about 43% below KETOCONAZOLE 2% CREAM.
Who manufactures KETOCONAZOLE 2% CREAM?
KETOCONAZOLE 2% CREAM (NDC 21922002504) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.