Product Information
CLINDA-TRETINOIN 1.2%-0.025% is a generic product labeled by Encube Ethicals, Inc., priced at $4.3119 per GM under NDC 21922005005. Its NADAC has been published 130 times since Apr 10, 2024.
FDA first approved this application on Sep 1, 2023. Its Orange Book therapeutic-equivalence code is AB2 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
10; .25 mg/g; mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922005005
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
CLINDAMYCIN PHOSPHATE; TRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA216943FDA Approved
9/1/2023
TE Code
AB2
On Market Since
9/4/2023
Pharmacological Classes
Price Statistics
The NADAC for CLINDA-TRETINOIN 1.2%-0.025% has been published 130 times since Apr 10, 2024, and over the history we have for it it has declined 34.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $4.3119 per GM |
|---|---|
| All-time high | $6.5446 (Apr 10, 2024) |
| All-time low | $4.3119 (Sep 23, 2026) |
| 52-week high | $4.9717 |
| 52-week low | $4.3119 |
| Median price | $4.9178 |
| Average price | $5.0325 |
| Largest weekly change | -25.0% (Apr 17, 2024) |
| Weeks tracked | 130 |
| Tracking since | Apr 10, 2024 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 19% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Encube Ethicals, Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Clindamycin Phosphate and Tretinoin Gel 1.2%/0.025% market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Lincosamide Antibacterial class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of CLINDA-TRETINOIN 1.2%-0.025%?
The current National Average Drug Acquisition Cost (NADAC) for CLINDA-TRETINOIN 1.2%-0.025%, manufactured by Encube Ethicals, Inc., is $4.3119 per GM (NDC 21922005005), effective Sep 30, 2026.
How has the price of CLINDA-TRETINOIN 1.2%-0.025% changed over time?
Over the history we have for it, the NADAC for CLINDA-TRETINOIN 1.2%-0.025% has declined 34.1%. It has been tracked across 130 weekly CMS publications since Apr 10, 2024.
What are the highest and lowest recorded NADAC prices for CLINDA-TRETINOIN 1.2%-0.025%?
Since Apr 10, 2024, the NADAC for CLINDA-TRETINOIN 1.2%-0.025% has ranged from a low of $4.3119 (Sep 23, 2026) to a high of $6.5446 (Apr 10, 2024), with a median of $4.9178 per GM.
Are there cheaper alternatives to CLINDA-TRETINOIN 1.2%-0.025%?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CLINDA-TRETINOIN 1.2%-0.025%, is $3.5063 per GM — about 19% below CLINDA-TRETINOIN 1.2%-0.025%.
Who manufactures CLINDA-TRETINOIN 1.2%-0.025%?
CLINDA-TRETINOIN 1.2%-0.025% (NDC 21922005005) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.