Product Information
FLUOCINONIDE 0.05% CREAM is a generic product labeled by Encube Ethicals, Inc., priced at $0.4145 per GM under NDC 21922006404. Its NADAC has been published 33 times since Jan 7, 2026.
FDA first approved this application on Oct 16, 2018. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922006404
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
FLUOCINONIDEApproval Type
Generic (ANDA)
FDA Application
ANDA211410FDA Approved
10/16/2018
TE Code
AB1
On Market Since
2/25/2025
Pharmacological Classes
Price Statistics
The NADAC for FLUOCINONIDE 0.05% CREAM has been published 33 times since Jan 7, 2026, and over the history we have for it it has risen 26.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.4145 per GM |
|---|---|
| All-time high | $0.4740 (Jun 10, 2026) |
| All-time low | $0.3028 (Feb 18, 2026) |
| 52-week high | $0.4740 |
| 52-week low | $0.3028 |
| Median price | $0.3928 |
| Average price | $0.3887 |
| Largest weekly change | +26.8% (Apr 22, 2026) |
| Weeks tracked | 33 |
| Tracking since | Jan 7, 2026 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 42% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of FLUOCINONIDE 0.05% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for FLUOCINONIDE 0.05% CREAM, manufactured by Encube Ethicals, Inc., is $0.4145 per GM (NDC 21922006404), effective Aug 19, 2026.
How has the price of FLUOCINONIDE 0.05% CREAM changed over time?
Over the history we have for it, the NADAC for FLUOCINONIDE 0.05% CREAM has risen 26.7%. It has been tracked across 33 weekly CMS publications since Jan 7, 2026.
What are the highest and lowest recorded NADAC prices for FLUOCINONIDE 0.05% CREAM?
Since Jan 7, 2026, the NADAC for FLUOCINONIDE 0.05% CREAM has ranged from a low of $0.3028 (Feb 18, 2026) to a high of $0.4740 (Jun 10, 2026), with a median of $0.3928 per GM.
Are there cheaper alternatives to FLUOCINONIDE 0.05% CREAM?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, FLUOCINONIDE 0.05% CREAM, is $0.2402 per GM — about 42% below FLUOCINONIDE 0.05% CREAM.
Who manufactures FLUOCINONIDE 0.05% CREAM?
FLUOCINONIDE 0.05% CREAM (NDC 21922006404) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.