Product Information
FLUOCINONIDE 0.05% CREAM is a generic product labeled by Encube Ethicals, Inc., priced at $0.2172 per GM under NDC 21922006407. Its NADAC has been published 39 times since Jan 7, 2026.
FDA first approved this application on Oct 16, 2018. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922006407
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
FLUOCINONIDEApproval Type
Generic (ANDA)
FDA Application
ANDA211410FDA Approved
10/16/2018
TE Code
AB1
On Market Since
2/25/2025
Pharmacological Classes
Price Statistics
The NADAC for FLUOCINONIDE 0.05% CREAM has been published 39 times since Jan 7, 2026, and over the history we have for it it has declined 32.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.2172 per GM |
|---|---|
| All-time high | $0.3224 (Feb 11, 2026) |
| All-time low | $0.2172 (Sep 23, 2026) |
| 52-week high | $0.3224 |
| 52-week low | $0.2172 |
| Median price | $0.2587 |
| Average price | $0.2749 |
| Largest weekly change | -9.6% (Sep 23, 2026) |
| Weeks tracked | 39 |
| Tracking since | Jan 7, 2026 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Encube Ethicals, Inc. manufacturer profile
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Drug market
Fluocinonide market comparison
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Therapeutic class
Corticosteroid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of FLUOCINONIDE 0.05% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for FLUOCINONIDE 0.05% CREAM, manufactured by Encube Ethicals, Inc., is $0.2172 per GM (NDC 21922006407), effective Sep 30, 2026.
How has the price of FLUOCINONIDE 0.05% CREAM changed over time?
Over the history we have for it, the NADAC for FLUOCINONIDE 0.05% CREAM has declined 32.3%. It has been tracked across 39 weekly CMS publications since Jan 7, 2026.
What are the highest and lowest recorded NADAC prices for FLUOCINONIDE 0.05% CREAM?
Since Jan 7, 2026, the NADAC for FLUOCINONIDE 0.05% CREAM has ranged from a low of $0.2172 (Sep 23, 2026) to a high of $0.3224 (Feb 11, 2026), with a median of $0.2587 per GM.
Are there cheaper alternatives to FLUOCINONIDE 0.05% CREAM?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as FLUOCINONIDE 0.05% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures FLUOCINONIDE 0.05% CREAM?
FLUOCINONIDE 0.05% CREAM (NDC 21922006407) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.