Product Information
LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM is a generic product labeled by Encube Ethicals, Inc., priced at $0.2211 per GM under NDC 21922007605. Its NADAC has been published 74 times since Mar 26, 2025.
FDA first approved this application on Aug 27, 2003. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25; 25 mg/g; mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922007605
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
LIDOCAINE; PRILOCAINEApproval Type
Generic (ANDA)
FDA Application
ANDA076320FDA Approved
8/27/2003
TE Code
AB
On Market Since
12/12/2024
Pharmacological Classes
Price Statistics
The NADAC for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM has been published 74 times since Mar 26, 2025, and over the history we have for it it has declined 24.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.2211 per GM |
|---|---|
| All-time high | $0.2942 (Apr 16, 2025) |
| All-time low | $0.2164 (Jun 17, 2026) |
| 52-week high | $0.2733 |
| 52-week low | $0.2164 |
| Median price | $0.2702 |
| Average price | $0.2583 |
| Largest weekly change | -6.4% (Mar 18, 2026) |
| Weeks tracked | 74 |
| Tracking since | Mar 26, 2025 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the LIDOCAINE AND PRILOCAINE market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM, manufactured by Encube Ethicals, Inc., is $0.2211 per GM (NDC 21922007605), effective Aug 19, 2026.
How has the price of LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM changed over time?
Over the history we have for it, the NADAC for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM has declined 24.8%. It has been tracked across 74 weekly CMS publications since Mar 26, 2025.
What are the highest and lowest recorded NADAC prices for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
Since Mar 26, 2025, the NADAC for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM has ranged from a low of $0.2164 (Jun 17, 2026) to a high of $0.2942 (Apr 16, 2025), with a median of $0.2702 per GM.
Are there cheaper alternatives to LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
No other NADAC-published product currently shares the active ingredient and strength of LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM (NDC 21922007605) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.