Product Information

NAPROXEN SOD CR 500 MG TABLET is a generic product labeled by Upsher-Smith Laboratories LLC, priced at $9.5851 per EA under NDC 24979025368. Its NADAC has been published 90 times since Dec 4, 2024.

FDA first approved this application on Jan 5, 1996. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.

The High Outlier badge above means this manufacturer's average price in the Naproxen Sodium market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.

NAPROXEN SOD CR 500 MG TABLET

Naproxen Sodium
$9.5851per EA
High Outlier

Strength

500 mg/1

NDC

24979025368

Classification

Generic

Dosage Form

TABLET, FILM COATED, EXTENDED RELEASE

Route

ORAL

Effective Date

8/19/2026

Active Ingredients

NAPROXEN SODIUM

Approval Type

Authorized Generic (NDA)

FDA Application

NDA020353

FDA Approved

1/5/1996

TE Code

AB

On Market Since

4/25/2024

Pharmacological Classes

Anti-Inflammatory Agents
Non-Steroidal
Cyclooxygenase Inhibitors
Nonsteroidal Anti-inflammatory Drug

Price Statistics

The NADAC for NAPROXEN SOD CR 500 MG TABLET has been published 90 times since Dec 4, 2024, and over the history we have for it it has risen 3.8%. The table below summarizes its recorded NADAC range and movement.

Current price$9.5851 per EA
All-time high$9.5930 (Aug 12, 2026)
All-time low$8.1286 (Dec 17, 2025)
52-week high$9.5930
52-week low$8.1286
Median price$9.0080
Average price$8.9746
Largest weekly change+5.4% (Jun 18, 2025)
Weeks tracked90
Tracking sinceDec 4, 2024

Price History

1W

-0.1%

1M

-0.1%

3M

+3.3%

6M

+12.7%

1Y

+3.3%

3Y

N/A

5Y

N/A

All

+3.8%

Generic Alternatives

The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.

Lowest-Cost Alternatives

1 alternative • Same active ingredient

Frequently asked questions

What is the NADAC price of NAPROXEN SOD CR 500 MG TABLET?

The current National Average Drug Acquisition Cost (NADAC) for NAPROXEN SOD CR 500 MG TABLET, manufactured by Upsher-Smith Laboratories LLC, is $9.5851 per EA (NDC 24979025368), effective Aug 19, 2026.

How has the price of NAPROXEN SOD CR 500 MG TABLET changed over time?

Over the history we have for it, the NADAC for NAPROXEN SOD CR 500 MG TABLET has risen 3.8%. It has been tracked across 90 weekly CMS publications since Dec 4, 2024.

What are the highest and lowest recorded NADAC prices for NAPROXEN SOD CR 500 MG TABLET?

Since Dec 4, 2024, the NADAC for NAPROXEN SOD CR 500 MG TABLET has ranged from a low of $8.1286 (Dec 17, 2025) to a high of $9.5930 (Aug 12, 2026), with a median of $9.0080 per EA.

Are there cheaper alternatives to NAPROXEN SOD CR 500 MG TABLET?

1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as NAPROXEN SOD CR 500 MG TABLET in a comparable dosage form, but none are currently priced below it.

Who manufactures NAPROXEN SOD CR 500 MG TABLET?

NAPROXEN SOD CR 500 MG TABLET (NDC 24979025368) is labeled by Upsher-Smith Laboratories LLC, and CMS classifies it as a generic product.