Product Information
PROTRIPTYLINE HCL 10 MG TABLET is a generic product labeled by Epic Pharma LLC, priced at $2.7110 per EA under NDC 42806009730. Its NADAC has been published 312 times since Oct 14, 2020.
FDA first approved this application on Nov 19, 2012. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
10 mg/1
Manufacturer
Epic Pharma LLCNDC
42806009730
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
PROTRIPTYLINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA202220FDA Approved
11/19/2012
TE Code
AB
On Market Since
1/9/2013
Pharmacological Classes
Price Statistics
The NADAC for PROTRIPTYLINE HCL 10 MG TABLET has been published 312 times since Oct 14, 2020, and over the history we have for it it has declined 15.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.7110 per EA |
|---|---|
| All-time high | $3.4886 (Jan 12, 2022) |
| All-time low | $2.0871 (Dec 23, 2020) |
| 52-week high | $3.1775 |
| 52-week low | $2.6976 |
| Median price | $2.8268 |
| Average price | $2.8387 |
| Largest weekly change | +47.4% (Jan 20, 2021) |
| Weeks tracked | 312 |
| Tracking since | Oct 14, 2020 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Epic Pharma LLC manufacturer profile
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Drug market
Protriptyline Hydrochloride market comparison
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Therapeutic class
Tricyclic Antidepressant class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of PROTRIPTYLINE HCL 10 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for PROTRIPTYLINE HCL 10 MG TABLET, manufactured by Epic Pharma LLC, is $2.7110 per EA (NDC 42806009730), effective Sep 30, 2026.
How has the price of PROTRIPTYLINE HCL 10 MG TABLET changed over time?
Over the history we have for it, the NADAC for PROTRIPTYLINE HCL 10 MG TABLET has declined 15.8%. It has been tracked across 312 weekly CMS publications since Oct 14, 2020.
What are the highest and lowest recorded NADAC prices for PROTRIPTYLINE HCL 10 MG TABLET?
Since Oct 14, 2020, the NADAC for PROTRIPTYLINE HCL 10 MG TABLET has ranged from a low of $2.0871 (Dec 23, 2020) to a high of $3.4886 (Jan 12, 2022), with a median of $2.8268 per EA.
Are there cheaper alternatives to PROTRIPTYLINE HCL 10 MG TABLET?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as PROTRIPTYLINE HCL 10 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures PROTRIPTYLINE HCL 10 MG TABLET?
PROTRIPTYLINE HCL 10 MG TABLET (NDC 42806009730) is labeled by Epic Pharma LLC, and CMS classifies it as a generic product.