Product Information
LEUCOVORIN CALCIUM 5 MG TAB is a generic product labeled by Epic Pharma LLC, priced at $0.3300 per EA under NDC 42806035801. Its NADAC has been published 312 times since Oct 14, 2020.
FDA first approved this application on Aug 28, 1997. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
5 mg/1
Manufacturer
Epic Pharma LLCNDC
42806035801
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
LEUCOVORIN CALCIUMApproval Type
Generic (ANDA)
FDA Application
ANDA074544FDA Approved
8/28/1997
TE Code
AB
On Market Since
4/16/2020
Pharmacological Classes
Price Statistics
The NADAC for LEUCOVORIN CALCIUM 5 MG TAB has been published 312 times since Oct 14, 2020, and over the history we have for it it has declined 62.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.3300 per EA |
|---|---|
| All-time high | $0.8875 (Sep 15, 2021) |
| All-time low | $0.3019 (Feb 21, 2024) |
| 52-week high | $0.4406 |
| 52-week low | $0.3300 |
| Median price | $0.5643 |
| Average price | $0.6031 |
| Largest weekly change | +77.9% (Mar 20, 2024) |
| Weeks tracked | 312 |
| Tracking since | Oct 14, 2020 |
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Epic Pharma LLC manufacturer profile
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Drug market
Leucovorin Calcium market comparison
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Therapeutic class
Folate Analog class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of LEUCOVORIN CALCIUM 5 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for LEUCOVORIN CALCIUM 5 MG TAB, manufactured by Epic Pharma LLC, is $0.3300 per EA (NDC 42806035801), effective Sep 30, 2026.
How has the price of LEUCOVORIN CALCIUM 5 MG TAB changed over time?
Over the history we have for it, the NADAC for LEUCOVORIN CALCIUM 5 MG TAB has declined 62.1%. It has been tracked across 312 weekly CMS publications since Oct 14, 2020.
What are the highest and lowest recorded NADAC prices for LEUCOVORIN CALCIUM 5 MG TAB?
Since Oct 14, 2020, the NADAC for LEUCOVORIN CALCIUM 5 MG TAB has ranged from a low of $0.3019 (Feb 21, 2024) to a high of $0.8875 (Sep 15, 2021), with a median of $0.5643 per EA.
Are there cheaper alternatives to LEUCOVORIN CALCIUM 5 MG TAB?
4 manufacturers publish a NADAC-priced product with the same active ingredient and strength as LEUCOVORIN CALCIUM 5 MG TAB in a comparable dosage form, but none are currently priced below it.
Who manufactures LEUCOVORIN CALCIUM 5 MG TAB?
LEUCOVORIN CALCIUM 5 MG TAB (NDC 42806035801) is labeled by Epic Pharma LLC, and CMS classifies it as a generic product.