Product Information
ACYCLOVIR 5% CREAM is a generic product labeled by Padagis Israel Pharmaceuticals Ltd, priced at $8.9916 per GM under NDC 45802004475. Its NADAC has been published 359 times since Nov 20, 2019.
FDA first approved this application on Feb 4, 2019. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The High Outlier badge above means this manufacturer's average price in the Acyclovir market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
50 mg/g
Manufacturer
Padagis Israel Pharmaceuticals LtdNDC
45802004475
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ACYCLOVIRApproval Type
Generic (ANDA)
FDA Application
ANDA208702FDA Approved
2/4/2019
TE Code
AB
On Market Since
2/11/2019
Pharmacological Classes
Price Statistics
The NADAC for ACYCLOVIR 5% CREAM has been published 359 times since Nov 20, 2019, and over the history we have for it it has declined 93.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $8.9916 per GM |
|---|---|
| All-time high | $144.8933 (Jan 15, 2020) |
| All-time low | $7.9189 (Nov 20, 2024) |
| 52-week high | $11.5170 |
| 52-week low | $8.9916 |
| Median price | $38.0650 |
| Average price | $51.9039 |
| Largest weekly change | +94.9% (Sep 22, 2021) |
| Weeks tracked | 359 |
| Tracking since | Nov 20, 2019 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Padagis Israel Pharmaceuticals Ltd manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Acyclovir market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ACYCLOVIR 5% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for ACYCLOVIR 5% CREAM, manufactured by Padagis Israel Pharmaceuticals Ltd, is $8.9916 per GM (NDC 45802004475), effective Sep 30, 2026.
How has the price of ACYCLOVIR 5% CREAM changed over time?
Over the history we have for it, the NADAC for ACYCLOVIR 5% CREAM has declined 93.8%. It has been tracked across 359 weekly CMS publications since Nov 20, 2019.
What are the highest and lowest recorded NADAC prices for ACYCLOVIR 5% CREAM?
Since Nov 20, 2019, the NADAC for ACYCLOVIR 5% CREAM has ranged from a low of $7.9189 (Nov 20, 2024) to a high of $144.8933 (Jan 15, 2020), with a median of $38.0650 per GM.
Are there cheaper alternatives to ACYCLOVIR 5% CREAM?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as ACYCLOVIR 5% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures ACYCLOVIR 5% CREAM?
ACYCLOVIR 5% CREAM (NDC 45802004475) is labeled by Padagis Israel Pharmaceuticals Ltd, and CMS classifies it as a generic product.