Product Information
NASAL SPRAY ORIGINAL 0.05% is a generic product labeled by AmerisourceBergen, priced at $0.0752 per ML under NDC 46122016510. Its NADAC has been published 671 times since Nov 28, 2013.
Strength
.05 g/100mL
Manufacturer
AmerisourceBergenNDC
46122016510
Classification
Generic
Dosage Form
SPRAY
Route
NASAL
Effective Date
9/23/2026
Active Ingredients
OXYMETAZOLINE HYDROCHLORIDEApproval Type
OTC MONOGRAPH DRUG
FDA Application
M012On Market Since
1/15/1990
Pharmacological Classes
Price Statistics
The NADAC for NASAL SPRAY ORIGINAL 0.05% has been published 671 times since Nov 28, 2013, and over the history we have for it it has risen 40.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0752 per ML |
|---|---|
| All-time high | $0.0820 (Jul 12, 2023) |
| All-time low | $0.0503 (Sep 17, 2014) |
| 52-week high | $0.0778 |
| 52-week low | $0.0706 |
| Median price | $0.0595 |
| Average price | $0.0628 |
| Largest weekly change | +24.6% (Jan 18, 2023) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 17% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
AmerisourceBergen manufacturer profile
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Drug market
oxymetazoline hydrochloride market comparison
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Therapeutic class
Vasoconstrictor class view
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Trend hub
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of NASAL SPRAY ORIGINAL 0.05%?
The current National Average Drug Acquisition Cost (NADAC) for NASAL SPRAY ORIGINAL 0.05%, manufactured by AmerisourceBergen, is $0.0752 per ML (NDC 46122016510), effective Sep 30, 2026.
How has the price of NASAL SPRAY ORIGINAL 0.05% changed over time?
Over the history we have for it, the NADAC for NASAL SPRAY ORIGINAL 0.05% has risen 40.0%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for NASAL SPRAY ORIGINAL 0.05%?
Since Nov 28, 2013, the NADAC for NASAL SPRAY ORIGINAL 0.05% has ranged from a low of $0.0503 (Sep 17, 2014) to a high of $0.0820 (Jul 12, 2023), with a median of $0.0595 per ML.
Are there cheaper alternatives to NASAL SPRAY ORIGINAL 0.05%?
Yes. 5 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, NASAL SPRAY 0.05%, is $0.0625 per ML — about 17% below NASAL SPRAY ORIGINAL 0.05%.
Who manufactures NASAL SPRAY ORIGINAL 0.05%?
NASAL SPRAY ORIGINAL 0.05% (NDC 46122016510) is labeled by AmerisourceBergen, and CMS classifies it as a generic product.