Product Information
NAPROXEN-ESOMEPRAZ DR 500-20 MG is a generic product labeled by ScieGen Pharmaceuticals Inc., priced at $1.9583 per EA under NDC 50228043860. Its NADAC has been published 104 times since Oct 9, 2024.
FDA first approved this application on Oct 11, 2023. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
20; 500 mg/1; mg/1
Manufacturer
ScieGen Pharmaceuticals Inc.NDC
50228043860
Classification
Generic
Dosage Form
TABLET, DELAYED RELEASE
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
ESOMEPRAZOLE MAGNESIUM; NAPROXENApproval Type
Generic (ANDA)
FDA Application
ANDA217738FDA Approved
10/11/2023
TE Code
AB
On Market Since
10/11/2023
Pharmacological Classes
Price Statistics
The NADAC for NAPROXEN-ESOMEPRAZ DR 500-20 MG has been published 104 times since Oct 9, 2024, and over the history we have for it it has declined 62.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.9583 per EA |
|---|---|
| All-time high | $5.3011 (Jan 15, 2025) |
| All-time low | $1.9583 (Sep 23, 2026) |
| 52-week high | $2.5858 |
| 52-week low | $1.9583 |
| Median price | $2.5794 |
| Average price | $3.3017 |
| Largest weekly change | -13.9% (May 21, 2025) |
| Weeks tracked | 104 |
| Tracking since | Oct 9, 2024 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
ScieGen Pharmaceuticals Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Naproxen and esomeprazole magnesium market comparison
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Therapeutic class
Nonsteroidal Anti-inflammatory Drug class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of NAPROXEN-ESOMEPRAZ DR 500-20 MG?
The current National Average Drug Acquisition Cost (NADAC) for NAPROXEN-ESOMEPRAZ DR 500-20 MG, manufactured by ScieGen Pharmaceuticals Inc., is $1.9583 per EA (NDC 50228043860), effective Sep 30, 2026.
How has the price of NAPROXEN-ESOMEPRAZ DR 500-20 MG changed over time?
Over the history we have for it, the NADAC for NAPROXEN-ESOMEPRAZ DR 500-20 MG has declined 62.5%. It has been tracked across 104 weekly CMS publications since Oct 9, 2024.
What are the highest and lowest recorded NADAC prices for NAPROXEN-ESOMEPRAZ DR 500-20 MG?
Since Oct 9, 2024, the NADAC for NAPROXEN-ESOMEPRAZ DR 500-20 MG has ranged from a low of $1.9583 (Sep 23, 2026) to a high of $5.3011 (Jan 15, 2025), with a median of $2.5794 per EA.
Are there cheaper alternatives to NAPROXEN-ESOMEPRAZ DR 500-20 MG?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as NAPROXEN-ESOMEPRAZ DR 500-20 MG in a comparable dosage form, but none are currently priced below it.
Who manufactures NAPROXEN-ESOMEPRAZ DR 500-20 MG?
NAPROXEN-ESOMEPRAZ DR 500-20 MG (NDC 50228043860) is labeled by ScieGen Pharmaceuticals Inc., and CMS classifies it as a generic product.