Product Information
NAPROXEN-ESOMEPRAZ DR 500-20 MG is a generic product labeled by Dr. Reddy's Laboratories Inc., priced at $1.9583 per EA under NDC 55111070160. Its NADAC has been published 324 times since Jul 22, 2020.
FDA first approved this application on Feb 18, 2020. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
20; 500 mg/1; mg/1
Manufacturer
Dr. Reddy's Laboratories Inc.NDC
55111070160
Classification
Generic
Dosage Form
TABLET, DELAYED RELEASE
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
ESOMEPRAZOLE MAGNESIUM; NAPROXENApproval Type
Generic (ANDA)
FDA Application
ANDA204206FDA Approved
2/18/2020
TE Code
AB
On Market Since
2/18/2020
Pharmacological Classes
Price Statistics
The NADAC for NAPROXEN-ESOMEPRAZ DR 500-20 MG has been published 324 times since Jul 22, 2020, and over the history we have for it it has declined 90.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.9583 per EA |
|---|---|
| All-time high | $25.1793 (Sep 16, 2020) |
| All-time low | $1.9583 (Sep 23, 2026) |
| 52-week high | $2.5858 |
| 52-week low | $1.9583 |
| Median price | $5.3831 |
| Average price | $9.5890 |
| Largest weekly change | -39.8% (Mar 22, 2023) |
| Weeks tracked | 324 |
| Tracking since | Jul 22, 2020 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Dr. Reddy's Laboratories Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Naproxen and esomeprazole magnesium market comparison
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Therapeutic class
Nonsteroidal Anti-inflammatory Drug class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of NAPROXEN-ESOMEPRAZ DR 500-20 MG?
The current National Average Drug Acquisition Cost (NADAC) for NAPROXEN-ESOMEPRAZ DR 500-20 MG, manufactured by Dr. Reddy's Laboratories Inc., is $1.9583 per EA (NDC 55111070160), effective Sep 30, 2026.
How has the price of NAPROXEN-ESOMEPRAZ DR 500-20 MG changed over time?
Over the history we have for it, the NADAC for NAPROXEN-ESOMEPRAZ DR 500-20 MG has declined 90.7%. It has been tracked across 324 weekly CMS publications since Jul 22, 2020.
What are the highest and lowest recorded NADAC prices for NAPROXEN-ESOMEPRAZ DR 500-20 MG?
Since Jul 22, 2020, the NADAC for NAPROXEN-ESOMEPRAZ DR 500-20 MG has ranged from a low of $1.9583 (Sep 23, 2026) to a high of $25.1793 (Sep 16, 2020), with a median of $5.3831 per EA.
Are there cheaper alternatives to NAPROXEN-ESOMEPRAZ DR 500-20 MG?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as NAPROXEN-ESOMEPRAZ DR 500-20 MG in a comparable dosage form, but none are currently priced below it.
Who manufactures NAPROXEN-ESOMEPRAZ DR 500-20 MG?
NAPROXEN-ESOMEPRAZ DR 500-20 MG (NDC 55111070160) is labeled by Dr. Reddy's Laboratories Inc., and CMS classifies it as a generic product.