Product Information
AMITRIPTYLINE HCL 75 MG TAB is a generic product labeled by AvPAK, priced at $0.1140 per EA under NDC 50268004015. Its NADAC has been published 150 times since Oct 11, 2023.
FDA first approved this application on May 19, 2021. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The Low Outlier badge above means this manufacturer's average price in the Amitriptyline Hydrochloride market falls below Q1 − 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
75 mg/1
Manufacturer
AvPAKNDC
50268004015
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
AMITRIPTYLINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA214548FDA Approved
5/19/2021
TE Code
AB
On Market Since
6/6/2023
Pharmacological Classes
Price Statistics
The NADAC for AMITRIPTYLINE HCL 75 MG TAB has been published 150 times since Oct 11, 2023, and over the history we have for it it has declined 5.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1140 per EA |
|---|---|
| All-time high | $0.1882 (Apr 10, 2024) |
| All-time low | $0.1009 (Feb 19, 2025) |
| 52-week high | $0.1344 |
| 52-week low | $0.1100 |
| Median price | $0.1198 |
| Average price | $0.1288 |
| Largest weekly change | +51.9% (Oct 18, 2023) |
| Weeks tracked | 150 |
| Tracking since | Oct 11, 2023 |
Generic Alternatives
The matcher finds 9 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of AMITRIPTYLINE HCL 75 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for AMITRIPTYLINE HCL 75 MG TAB, manufactured by AvPAK, is $0.1140 per EA (NDC 50268004015), effective Aug 19, 2026.
How has the price of AMITRIPTYLINE HCL 75 MG TAB changed over time?
Over the history we have for it, the NADAC for AMITRIPTYLINE HCL 75 MG TAB has declined 5.4%. It has been tracked across 150 weekly CMS publications since Oct 11, 2023.
What are the highest and lowest recorded NADAC prices for AMITRIPTYLINE HCL 75 MG TAB?
Since Oct 11, 2023, the NADAC for AMITRIPTYLINE HCL 75 MG TAB has ranged from a low of $0.1009 (Feb 19, 2025) to a high of $0.1882 (Apr 10, 2024), with a median of $0.1198 per EA.
Are there cheaper alternatives to AMITRIPTYLINE HCL 75 MG TAB?
9 manufacturers publish a NADAC-priced product with the same active ingredient and strength as AMITRIPTYLINE HCL 75 MG TAB in a comparable dosage form, but none are currently priced below it.
Who manufactures AMITRIPTYLINE HCL 75 MG TAB?
AMITRIPTYLINE HCL 75 MG TAB (NDC 50268004015) is labeled by AvPAK, and CMS classifies it as a generic product.