Product Information
TRAMADOL-ACETAMINOPHEN 37.5-325 MG TAB is a generic product labeled by AvPAK, priced at $0.1159 per EA under NDC 50268077415. Its NADAC has been published 464 times since Nov 15, 2017.
FDA first approved this application on Dec 9, 2009. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
325; 37.5 mg/1; mg/1
Manufacturer
AvPAKNDC
50268077415
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
ACETAMINOPHEN; TRAMADOL HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA090485FDA Approved
12/9/2009
TE Code
AB
On Market Since
1/14/2015
Pharmacological Classes
Price Statistics
The NADAC for TRAMADOL-ACETAMINOPHEN 37.5-325 MG TAB has been published 464 times since Nov 15, 2017, and over the history we have for it it has declined 29.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1159 per EA |
|---|---|
| All-time high | $0.1758 (Sep 12, 2018) |
| All-time low | $0.0806 (Nov 20, 2024) |
| 52-week high | $0.1159 |
| 52-week low | $0.1014 |
| Median price | $0.1181 |
| Average price | $0.1224 |
| Largest weekly change | +26.7% (Aug 21, 2024) |
| Weeks tracked | 464 |
| Tracking since | Nov 15, 2017 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
AvPAK manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Tramadol Hydrochloride and Acetaminophen market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Opioid Agonist class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of TRAMADOL-ACETAMINOPHEN 37.5-325 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for TRAMADOL-ACETAMINOPHEN 37.5-325 MG TAB, manufactured by AvPAK, is $0.1159 per EA (NDC 50268077415), effective Sep 30, 2026.
How has the price of TRAMADOL-ACETAMINOPHEN 37.5-325 MG TAB changed over time?
Over the history we have for it, the NADAC for TRAMADOL-ACETAMINOPHEN 37.5-325 MG TAB has declined 29.6%. It has been tracked across 464 weekly CMS publications since Nov 15, 2017.
What are the highest and lowest recorded NADAC prices for TRAMADOL-ACETAMINOPHEN 37.5-325 MG TAB?
Since Nov 15, 2017, the NADAC for TRAMADOL-ACETAMINOPHEN 37.5-325 MG TAB has ranged from a low of $0.0806 (Nov 20, 2024) to a high of $0.1758 (Sep 12, 2018), with a median of $0.1181 per EA.
Are there cheaper alternatives to TRAMADOL-ACETAMINOPHEN 37.5-325 MG TAB?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as TRAMADOL-ACETAMINOPHEN 37.5-325 MG TAB in a comparable dosage form, but none are currently priced below it.
Who manufactures TRAMADOL-ACETAMINOPHEN 37.5-325 MG TAB?
TRAMADOL-ACETAMINOPHEN 37.5-325 MG TAB (NDC 50268077415) is labeled by AvPAK, and CMS classifies it as a generic product.