Product Information
SPRAVATO 84 MG DOSE PACK is a brand product labeled by Janssen Pharmaceuticals Inc., priced at $429.9791 per EA under NDC 50458002803. Its NADAC has been published 120 times since Jun 19, 2024.
FDA first approved this application on Mar 5, 2019.
Strength
28 mg/.2mL
Manufacturer
Janssen Pharmaceuticals Inc.NDC
50458002803
Classification
Brand
Dosage Form
SOLUTION
Route
NASAL
Effective Date
9/23/2026
Active Ingredients
ESKETAMINE HYDROCHLORIDEApproval Type
New Drug (NDA)
FDA Application
NDA211243FDA Approved
3/5/2019
On Market Since
3/5/2019
Price Statistics
The NADAC for SPRAVATO 84 MG DOSE PACK has been published 120 times since Jun 19, 2024, and over the history we have for it it has risen 15.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $429.9791 per EA |
|---|---|
| All-time high | $431.7743 (Aug 12, 2026) |
| All-time low | $371.0541 (Dec 18, 2024) |
| 52-week high | $431.7743 |
| 52-week low | $397.7311 |
| Median price | $399.1012 |
| Average price | $400.5709 |
| Largest weekly change | +8.0% (Feb 5, 2025) |
| Weeks tracked | 120 |
| Tracking since | Jun 19, 2024 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 1% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Janssen Pharmaceuticals Inc. manufacturer profile
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Drug market
Esketamine Hydrochloride market comparison
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of SPRAVATO 84 MG DOSE PACK?
The current National Average Drug Acquisition Cost (NADAC) for SPRAVATO 84 MG DOSE PACK, manufactured by Janssen Pharmaceuticals Inc., is $429.9791 per EA (NDC 50458002803), effective Sep 30, 2026.
How has the price of SPRAVATO 84 MG DOSE PACK changed over time?
Over the history we have for it, the NADAC for SPRAVATO 84 MG DOSE PACK has risen 15.0%. It has been tracked across 120 weekly CMS publications since Jun 19, 2024.
What are the highest and lowest recorded NADAC prices for SPRAVATO 84 MG DOSE PACK?
Since Jun 19, 2024, the NADAC for SPRAVATO 84 MG DOSE PACK has ranged from a low of $371.0541 (Dec 18, 2024) to a high of $431.7743 (Aug 12, 2026), with a median of $399.1012 per EA.
Are there cheaper alternatives to SPRAVATO 84 MG DOSE PACK?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, SPRAVATO 56 MG DOSE PACK, is $426.2990 per EA — about 1% below SPRAVATO 84 MG DOSE PACK.
Who manufactures SPRAVATO 84 MG DOSE PACK?
SPRAVATO 84 MG DOSE PACK (NDC 50458002803) is labeled by Janssen Pharmaceuticals Inc., and CMS classifies it as a brand product.