Product Information
FLUOROURACIL 5% CREAM is a generic product labeled by Mayne Pharma, priced at $0.6156 per GM under NDC 51862036240. Its NADAC has been published 347 times since Feb 12, 2020.
FDA first approved this application on Apr 11, 2008. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
50 mg/g
Manufacturer
Mayne PharmaNDC
51862036240
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
FLUOROURACILApproval Type
Generic (ANDA)
FDA Application
ANDA077524FDA Approved
4/11/2008
TE Code
AB
On Market Since
12/3/2019
Pharmacological Classes
Price Statistics
The NADAC for FLUOROURACIL 5% CREAM has been published 347 times since Feb 12, 2020, and over the history we have for it it has declined 70.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.6156 per GM |
|---|---|
| All-time high | $2.1046 (Feb 12, 2020) |
| All-time low | $0.5853 (Jul 22, 2026) |
| 52-week high | $0.6858 |
| 52-week low | $0.5853 |
| Median price | $0.8408 |
| Average price | $1.0935 |
| Largest weekly change | +30.8% (Nov 22, 2023) |
| Weeks tracked | 347 |
| Tracking since | Feb 12, 2020 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Mayne Pharma manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
FLUOROURACIL market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Nucleoside Metabolic Inhibitor class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of FLUOROURACIL 5% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for FLUOROURACIL 5% CREAM, manufactured by Mayne Pharma, is $0.6156 per GM (NDC 51862036240), effective Sep 30, 2026.
How has the price of FLUOROURACIL 5% CREAM changed over time?
Over the history we have for it, the NADAC for FLUOROURACIL 5% CREAM has declined 70.7%. It has been tracked across 347 weekly CMS publications since Feb 12, 2020.
What are the highest and lowest recorded NADAC prices for FLUOROURACIL 5% CREAM?
Since Feb 12, 2020, the NADAC for FLUOROURACIL 5% CREAM has ranged from a low of $0.5853 (Jul 22, 2026) to a high of $2.1046 (Feb 12, 2020), with a median of $0.8408 per GM.
Are there cheaper alternatives to FLUOROURACIL 5% CREAM?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as FLUOROURACIL 5% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures FLUOROURACIL 5% CREAM?
FLUOROURACIL 5% CREAM (NDC 51862036240) is labeled by Mayne Pharma, and CMS classifies it as a generic product.