Fluorouracil
12 NDCs across 9 manufacturers|10 Generic,2 Brand
Fluorouracil is used to treat basal cell carcinoma, breast neoplasms, colonic neoplasms, head and neck neoplasms, keratosis and pancreatic neoplasms, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved before 1982, and the first generic was approved Oct 13, 1982. FDA's Orange Book lists 5 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $46 million on Fluorouracil across 679,000 claims for 584,000 beneficiaries.
Fluorouracil is available as 12 NDCs from 9 manufacturers (10 generic, 2 brand), with NADAC prices from $0.59 to $6.42 per GM — the most expensive product costs about 11× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
12
10G / 2B
Manufacturers
9
competing in market
Price Spread
$0.59 – $6.42
per GM, 9 of 12 NDCs
7d Activity
avg +0.6% WoW · of 12 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Taro Pharmaceuticals U.S.A. Inc. manufacturer profile
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Lead class
Nucleoside Metabolic Inhibitor class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
Review the benchmark methodology behind the prices and spreads shown on this market page.
Manufacturer Breakdown
9 manufacturers producing FLUOROURACIL(1 pricing outlier)
| Drug ↕ | Price | 7d Change ↕ |
|---|---|---|
TOLAK 4% CREAM | $6.4181 per GM | — |
FLUOROURACIL 5% TOPICAL SOLN | $4.1734 per ML | -0.80% |
FLUOROURACIL 5% TOPICAL SOLN | $4.1734 per ML | -0.80% |
FLUOROURACIL 2% TOPICAL SOLN | $3.4213 per ML | -5.26% |
EFUDEX 5% CREAM | $1.4420 per GM | — |
FLUOROURACIL 5% CREAM | $0.6156 per GM | +2.03% |
FLUOROURACIL 5% CREAM | $0.6156 per GM | +2.03% |
FLUOROURACIL 5% CREAM | $0.6156 per GM | +2.03% |
FLUOROURACIL 5% CREAM | $0.6156 per GM | +2.03% |
FLUOROURACIL 5% CREAM | $0.6156 per GM | +2.03% |
FLUOROURACIL 5% CREAM | $0.6156 per GM | +2.03% |
FLUOROURACIL 5% CREAM | $0.5918 per GM | — |
Frequently Asked Questions
What is Fluorouracil used to treat?
Fluorouracil is used to treat basal cell carcinoma, breast neoplasms, colonic neoplasms, head and neck neoplasms, keratosis and pancreatic neoplasms, per the National Library of Medicine's MED-RT classification.
When did Fluorouracil become available as a generic?
FDA approved the first generic Fluorouracil (ANDA) on Oct 13, 1982. The Orange Book currently lists 5 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Fluorouracil?
In 2024, Medicare Part D spent $46 million on Fluorouracil across 679,000 claims for 584,000 beneficiaries.
How many Fluorouracil products are on the market?
The Fluorouracil drug market contains 12 NDCs from 9 manufacturers — 10 generic and 2 brand products.
What is the price range for Fluorouracil?
NADAC reference prices for Fluorouracil range from $0.5918 to $6.4181 per GM — the most expensive product costs about 11× the cheapest. 3 additional products are priced per different units (e.g. liquids per ML) and aren't directly comparable.
Is generic Fluorouracil cheaper than brand?
The average generic NADAC for Fluorouracil is $0.6122 per GM, versus $3.9300 for brand-labeled products — brand versions average about 6.4× the generic price.
Which manufacturers make Fluorouracil?
9 manufacturers list Fluorouracil in NADAC. Ranked by number of NDCs, the largest are Taro Pharmaceuticals U.S.A. Inc. (3), Encube Ethicals, Inc. (2), HILL DERMACEUTICALS, INC. (1), Bausch Health US LLC (1), Dr. Reddy's Laboratories Inc. (1).
How has the price of Fluorouracil changed recently?
Over the past 7 days, 6 Fluorouracil NDCs rose and 3 fell, with a market-wide average change of +0.6%.