Product Information
OTREXUP 15 MG/0.4 ML AUTO-INJ is a brand product labeled by Antares Pharma, Inc., priced at $484.2097 per ML under NDC 54436001504. Its NADAC has been published 158 times since Jul 17, 2019.
The High Outlier badge above means this manufacturer's average price in the methotrexate market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
15 mg/.4mL
Manufacturer
Antares Pharma, Inc.NDC
54436001504
Classification
Brand
Dosage Form
INJECTION, SOLUTION
Route
SUBCUTANEOUS
Last Updated
4/1/2025
Active Ingredients
METHOTREXATEApproval Type
New Drug (NDA)
FDA Application
NDA204824On Market Since
10/11/2013
Pharmacological Classes
Price Statistics
The NADAC for OTREXUP 15 MG/0.4 ML AUTO-INJ has been published 158 times since Jul 17, 2019, and over the history we have for it it has risen 22.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $484.2097 per ML |
|---|---|
| All-time high | $484.2097 (Apr 15, 2026) |
| All-time low | $394.1338 (Jul 17, 2019) |
| 52-week high | $484.2097 |
| 52-week low | $484.2097 |
| Median price | $465.3569 |
| Average price | $448.7075 |
| Largest weekly change | +18.1% (Apr 17, 2024) |
| Weeks tracked | 158 |
| Tracking since | Jul 17, 2019 |
Generic Alternatives
The matcher finds 1 NADAC-published product sharing this drug's active ingredient, strength, and dosage form across 1 manufacturer (up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 0% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of OTREXUP 15 MG/0.4 ML AUTO-INJ?
The current National Average Drug Acquisition Cost (NADAC) for OTREXUP 15 MG/0.4 ML AUTO-INJ, manufactured by Antares Pharma, Inc., is $484.2097 per ML (NDC 54436001504), effective Apr 15, 2026.
How has the price of OTREXUP 15 MG/0.4 ML AUTO-INJ changed over time?
Over the history we have for it, the NADAC for OTREXUP 15 MG/0.4 ML AUTO-INJ has risen 22.9%. It has been tracked across 158 weekly CMS publications since Jul 17, 2019.
What are the highest and lowest recorded NADAC prices for OTREXUP 15 MG/0.4 ML AUTO-INJ?
Since Jul 17, 2019, the NADAC for OTREXUP 15 MG/0.4 ML AUTO-INJ has ranged from a low of $394.1338 (Jul 17, 2019) to a high of $484.2097 (Apr 15, 2026), with a median of $465.3569 per ML.
Are there cheaper alternatives to OTREXUP 15 MG/0.4 ML AUTO-INJ?
Yes. 1 NADAC-published product shares the same active ingredient, strength, and dosage form. The lowest-priced option, RASUVO 15 MG/0.3 ML AUTOINJ, is $482.2921 per ML — about 0% below OTREXUP 15 MG/0.4 ML AUTO-INJ.
Who manufactures OTREXUP 15 MG/0.4 ML AUTO-INJ?
OTREXUP 15 MG/0.4 ML AUTO-INJ (NDC 54436001504) is labeled by Antares Pharma, Inc., and CMS classifies it as a brand product.
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