Product Information
OTREXUP 25 MG/0.4 ML AUTO-INJ is a brand product labeled by Antares Pharma, Inc., priced at $475.8075 per ML under NDC 54436002504. Its NADAC has been published 167 times since Sep 23, 2020.
The High Outlier badge above means this manufacturer's average price in the methotrexate market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
25 mg/.4mL
Manufacturer
Antares Pharma, Inc.NDC
54436002504
Classification
Brand
Dosage Form
INJECTION, SOLUTION
Route
SUBCUTANEOUS
Last Updated
8/20/2025
Active Ingredients
METHOTREXATEApproval Type
New Drug (NDA)
FDA Application
NDA204824On Market Since
10/11/2013
Pharmacological Classes
Price Statistics
The NADAC for OTREXUP 25 MG/0.4 ML AUTO-INJ has been published 167 times since Sep 23, 2020, and over the history we have for it it has risen 21.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $475.8075 per ML |
|---|---|
| All-time high | $480.1503 (Aug 13, 2025) |
| All-time low | $391.2917 (Sep 23, 2020) |
| 52-week high | $480.1503 |
| 52-week low | $475.8075 |
| Median price | $466.4896 |
| Average price | $446.9641 |
| Largest weekly change | +18.9% (Apr 17, 2024) |
| Weeks tracked | 167 |
| Tracking since | Sep 23, 2020 |
Generic Alternatives
The matcher finds 1 NADAC-published product sharing this drug's active ingredient, strength, and dosage form across 1 manufacturer (up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 39% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of OTREXUP 25 MG/0.4 ML AUTO-INJ?
The current National Average Drug Acquisition Cost (NADAC) for OTREXUP 25 MG/0.4 ML AUTO-INJ, manufactured by Antares Pharma, Inc., is $475.8075 per ML (NDC 54436002504), effective Jun 24, 2026.
How has the price of OTREXUP 25 MG/0.4 ML AUTO-INJ changed over time?
Over the history we have for it, the NADAC for OTREXUP 25 MG/0.4 ML AUTO-INJ has risen 21.6%. It has been tracked across 167 weekly CMS publications since Sep 23, 2020.
What are the highest and lowest recorded NADAC prices for OTREXUP 25 MG/0.4 ML AUTO-INJ?
Since Sep 23, 2020, the NADAC for OTREXUP 25 MG/0.4 ML AUTO-INJ has ranged from a low of $391.2917 (Sep 23, 2020) to a high of $480.1503 (Aug 13, 2025), with a median of $466.4896 per ML.
Are there cheaper alternatives to OTREXUP 25 MG/0.4 ML AUTO-INJ?
Yes. 1 NADAC-published product shares the same active ingredient, strength, and dosage form. The lowest-priced option, RASUVO 25 MG/0.5 ML AUTOINJ, is $288.3819 per ML — about 39% below OTREXUP 25 MG/0.4 ML AUTO-INJ.
Who manufactures OTREXUP 25 MG/0.4 ML AUTO-INJ?
OTREXUP 25 MG/0.4 ML AUTO-INJ (NDC 54436002504) is labeled by Antares Pharma, Inc., and CMS classifies it as a brand product.
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