Product Information

CODEINE-GUAIFEN 10-100 MG/5 ML is a generic product labeled by Method Pharmaceuticals LLC, priced at $0.0575 per ML under NDC 58657050004. Its NADAC has been published 592 times since Apr 22, 2015.

CODEINE-GUAIFEN 10-100 MG/5 ML

Codeine Phosphate and Guaifenesin
$0.0575per ML
OTC
DEA Schedule CIII

Strength

10; 100 mg/5mL; mg/5mL

NDC

58657050004

Classification

Generic

Dosage Form

SOLUTION

Route

ORAL

Effective Date

8/19/2026

Approval Type

OTC MONOGRAPH DRUG

FDA Application

M012

On Market Since

4/1/2014

Pharmacological Classes

Decreased Respiratory Secretion Viscosity
Expectorant
Full Opioid Agonists
Increased Respiratory Secretions
Opioid Agonist

Price Statistics

The NADAC for CODEINE-GUAIFEN 10-100 MG/5 ML has been published 592 times since Apr 22, 2015, and over the history we have for it it has risen 8.7%. The table below summarizes its recorded NADAC range and movement.

Current price$0.0575 per ML
All-time high$0.0703 (Jan 10, 2018)
All-time low$0.0204 (Nov 23, 2022)
52-week high$0.0575
52-week low$0.0533
Median price$0.0497
Average price$0.0502
Largest weekly change+124.1% (Jan 18, 2023)
Weeks tracked592
Tracking sinceApr 22, 2015

Price History

1W

+3.8%

1M

+3.8%

3M

+7.8%

6M

+0.6%

1Y

+0.5%

3Y

+28.5%

5Y

+14.0%

All

+8.7%

Generic Alternatives

The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 42% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.

Frequently asked questions

What is the NADAC price of CODEINE-GUAIFEN 10-100 MG/5 ML?

The current National Average Drug Acquisition Cost (NADAC) for CODEINE-GUAIFEN 10-100 MG/5 ML, manufactured by Method Pharmaceuticals LLC, is $0.0575 per ML (NDC 58657050004), effective Aug 19, 2026.

How has the price of CODEINE-GUAIFEN 10-100 MG/5 ML changed over time?

Over the history we have for it, the NADAC for CODEINE-GUAIFEN 10-100 MG/5 ML has risen 8.7%. It has been tracked across 592 weekly CMS publications since Apr 22, 2015.

What are the highest and lowest recorded NADAC prices for CODEINE-GUAIFEN 10-100 MG/5 ML?

Since Apr 22, 2015, the NADAC for CODEINE-GUAIFEN 10-100 MG/5 ML has ranged from a low of $0.0204 (Nov 23, 2022) to a high of $0.0703 (Jan 10, 2018), with a median of $0.0497 per ML.

Are there cheaper alternatives to CODEINE-GUAIFEN 10-100 MG/5 ML?

Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CODEINE-GUAIFEN 10-100 MG/5 ML, is $0.0331 per ML — about 42% below CODEINE-GUAIFEN 10-100 MG/5 ML.

Who manufactures CODEINE-GUAIFEN 10-100 MG/5 ML?

CODEINE-GUAIFEN 10-100 MG/5 ML (NDC 58657050004) is labeled by Method Pharmaceuticals LLC, and CMS classifies it as a generic product.