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This NDC is on FDA's drug shortage list (posted Oct 14, 2016)

Product Information

XYLOCAINE 1%-EPI 1:100,000 is a brand product labeled by Fresenius Kabi USA, LLC, priced at $0.2721 per ML under NDC 63323048227. Its NADAC has been published 96 times since Apr 17, 2024.

FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AP.

XYLOCAINE 1%-EPI 1:100,000

LIDOCAINE HYDROCHLORIDE,EPINEPHRINE BITARTRATE
$0.2721per ML

Strength

.01; 10 mg/mL; mg/mL

NDC

63323048227

Classification

Brand

Dosage Form

INJECTION, SOLUTION

Route

INFILTRATION; PERINEURAL

Effective Date

2/1/2025

Approval Type

New Drug (NDA)

FDA Application

NDA006488

FDA Approved

Before 1982

TE Code

AP

On Market Since

8/12/2010

Pharmacological Classes

Adrenergic alpha-Agonists
Adrenergic beta-Agonists
Amide Local Anesthetic
Amides
Antiarrhythmic
Catecholamine
Catecholamines
Local Anesthesia
alpha-Adrenergic Agonist
beta-Adrenergic Agonist

Price Statistics

The NADAC for XYLOCAINE 1%-EPI 1:100,000 has been published 96 times since Apr 17, 2024, and over the history we have for it it has risen 14.0%. The table below summarizes its recorded NADAC range and movement.

Current price$0.2721 per ML
All-time high$0.2721 (Feb 11, 2026)
All-time low$0.2386 (Apr 17, 2024)
52-week high$0.2721
52-week low$0.2721
Median price$0.2721
Average price$0.2571
Largest weekly change+14.0% (Feb 12, 2025)
Weeks tracked96
Tracking sinceApr 17, 2024

Price History

1W

N/A

1M

N/A

3M

N/A

6M

N/A

1Y

0.0%

3Y

N/A

5Y

N/A

All

+14.0%

Last surveyed Feb 11, 2026 — this NDC no longer appears in the current weekly NADAC file.

Generic Alternatives

The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.

Lowest-Cost Alternatives

1 alternative • Same active ingredient

XYLOCAINE 1%-EPI 1:100,000
Brand
63323048226•Fresenius Kabi USA, LLC
$0.2721

Related Drugs

Same classification

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$0.0977
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SENSORCAINE 0.5% VIAL
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63323046757•Fresenius Kabi USA, LLC
$0.0977
per ML
VANACOF LIQUID
Brand
58809099901•GM Pharmaceuticals, INC
$0.1051
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SILVADENE 1% CREAM
Brand
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$0.1247
per GM
SILVADENE 1% CREAM
Brand
61570013150•Pfizer Inc.
$0.2447
per GM
SILVADENE 1% CREAM
Brand
61570013155•Pfizer Inc.
$0.2447
per GM
ADVIL COLD & SINUS CAPLET
Brand
00573018010•Haleon US Holdings LLC
$0.2615
per EA
ADVIL COLD & SINUS CAPLET
Brand
00573018021•Haleon US Holdings LLC
$0.2615
per EA
SILVADENE 1% CREAM
Brand
61570013185•Pfizer Inc.
$0.2732
per GM

Frequently asked questions

What is the NADAC price of XYLOCAINE 1%-EPI 1:100,000?

The current National Average Drug Acquisition Cost (NADAC) for XYLOCAINE 1%-EPI 1:100,000, manufactured by Fresenius Kabi USA, LLC, is $0.2721 per ML (NDC 63323048227), effective Feb 11, 2026.

How has the price of XYLOCAINE 1%-EPI 1:100,000 changed over time?

Over the history we have for it, the NADAC for XYLOCAINE 1%-EPI 1:100,000 has risen 14.0%. It has been tracked across 96 weekly CMS publications since Apr 17, 2024.

What are the highest and lowest recorded NADAC prices for XYLOCAINE 1%-EPI 1:100,000?

Since Apr 17, 2024, the NADAC for XYLOCAINE 1%-EPI 1:100,000 has ranged from a low of $0.2386 (Apr 17, 2024) to a high of $0.2721 (Feb 11, 2026), with a median of $0.2721 per ML.

Are there cheaper alternatives to XYLOCAINE 1%-EPI 1:100,000?

1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as XYLOCAINE 1%-EPI 1:100,000 in a comparable dosage form, but none are currently priced below it.

Who manufactures XYLOCAINE 1%-EPI 1:100,000?

XYLOCAINE 1%-EPI 1:100,000 (NDC 63323048227) is labeled by Fresenius Kabi USA, LLC, and CMS classifies it as a brand product.

Is XYLOCAINE 1%-EPI 1:100,000 in shortage?

Yes — NDC 63323048227 is currently listed in FDA's drug shortage database (posted Oct 14, 2016).