Product Information
DIFLORASONE 0.05% OINTMENT is a generic product labeled by Rising Pharma Holdings Inc., priced at $3.2501 per GM under NDC 64980012403. Its NADAC has been published 50 times since Oct 22, 2025.
FDA first approved this application on Feb 27, 2017. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/g
Manufacturer
Rising Pharma Holdings Inc.NDC
64980012403
Classification
Generic
Dosage Form
OINTMENT
Route
TOPICAL
Effective Date
5/20/2026
Active Ingredients
DIFLORASONE DIACETATEApproval Type
Generic (ANDA)
FDA Application
ANDA207440FDA Approved
2/27/2017
TE Code
AB
On Market Since
2/27/2017
Pharmacological Classes
Price Statistics
The NADAC for DIFLORASONE 0.05% OINTMENT has been published 50 times since Oct 22, 2025, and over the history we have for it it has risen 47.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $3.2501 per GM |
|---|---|
| All-time high | $4.3442 (Mar 11, 2026) |
| All-time low | $2.2037 (Oct 22, 2025) |
| 52-week high | $4.3442 |
| 52-week low | $2.2037 |
| Median price | $3.2501 |
| Average price | $3.3031 |
| Largest weekly change | +36.9% (Jan 21, 2026) |
| Weeks tracked | 50 |
| Tracking since | Oct 22, 2025 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 74% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Rising Pharma Holdings Inc. manufacturer profile
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Drug market
diflorasone diacetate market comparison
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Therapeutic class
Corticosteroid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of DIFLORASONE 0.05% OINTMENT?
The current National Average Drug Acquisition Cost (NADAC) for DIFLORASONE 0.05% OINTMENT, manufactured by Rising Pharma Holdings Inc., is $3.2501 per GM (NDC 64980012403), effective Sep 30, 2026.
How has the price of DIFLORASONE 0.05% OINTMENT changed over time?
Over the history we have for it, the NADAC for DIFLORASONE 0.05% OINTMENT has risen 47.5%. It has been tracked across 50 weekly CMS publications since Oct 22, 2025.
What are the highest and lowest recorded NADAC prices for DIFLORASONE 0.05% OINTMENT?
Since Oct 22, 2025, the NADAC for DIFLORASONE 0.05% OINTMENT has ranged from a low of $2.2037 (Oct 22, 2025) to a high of $4.3442 (Mar 11, 2026), with a median of $3.2501 per GM.
Are there cheaper alternatives to DIFLORASONE 0.05% OINTMENT?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, DIFLORASONE 0.05% OINTMENT, is $0.8514 per GM — about 74% below DIFLORASONE 0.05% OINTMENT.
Who manufactures DIFLORASONE 0.05% OINTMENT?
DIFLORASONE 0.05% OINTMENT (NDC 64980012403) is labeled by Rising Pharma Holdings Inc., and CMS classifies it as a generic product.