Product Information
DIFLORASONE 0.05% OINTMENT is a generic product labeled by Rising Pharma Holdings Inc., priced at $3.2501 per GM under NDC 64980012403. Its NADAC has been published 44 times since Oct 22, 2025.
FDA first approved this application on Feb 27, 2017. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/g
Manufacturer
Rising Pharma Holdings Inc.NDC
64980012403
Classification
Generic
Dosage Form
OINTMENT
Route
TOPICAL
Effective Date
5/20/2026
Active Ingredients
DIFLORASONE DIACETATEApproval Type
Generic (ANDA)
FDA Application
ANDA207440FDA Approved
2/27/2017
TE Code
AB
On Market Since
2/27/2017
Pharmacological Classes
Price Statistics
The NADAC for DIFLORASONE 0.05% OINTMENT has been published 44 times since Oct 22, 2025, and over the history we have for it it has risen 47.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $3.2501 per GM |
|---|---|
| All-time high | $4.3442 (Mar 11, 2026) |
| All-time low | $2.2037 (Oct 22, 2025) |
| 52-week high | $4.3442 |
| 52-week low | $2.2037 |
| Median price | $3.2501 |
| Average price | $3.3103 |
| Largest weekly change | +36.9% (Jan 21, 2026) |
| Weeks tracked | 44 |
| Tracking since | Oct 22, 2025 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 69% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of DIFLORASONE 0.05% OINTMENT?
The current National Average Drug Acquisition Cost (NADAC) for DIFLORASONE 0.05% OINTMENT, manufactured by Rising Pharma Holdings Inc., is $3.2501 per GM (NDC 64980012403), effective Aug 19, 2026.
How has the price of DIFLORASONE 0.05% OINTMENT changed over time?
Over the history we have for it, the NADAC for DIFLORASONE 0.05% OINTMENT has risen 47.5%. It has been tracked across 44 weekly CMS publications since Oct 22, 2025.
What are the highest and lowest recorded NADAC prices for DIFLORASONE 0.05% OINTMENT?
Since Oct 22, 2025, the NADAC for DIFLORASONE 0.05% OINTMENT has ranged from a low of $2.2037 (Oct 22, 2025) to a high of $4.3442 (Mar 11, 2026), with a median of $3.2501 per GM.
Are there cheaper alternatives to DIFLORASONE 0.05% OINTMENT?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, DIFLORASONE 0.05% OINTMENT, is $1.0050 per GM — about 69% below DIFLORASONE 0.05% OINTMENT.
Who manufactures DIFLORASONE 0.05% OINTMENT?
DIFLORASONE 0.05% OINTMENT (NDC 64980012403) is labeled by Rising Pharma Holdings Inc., and CMS classifies it as a generic product.