Product Information
LYLLANA 0.1 MG PATCH is a generic product labeled by Amneal Pharmaceuticals LLC, priced at $8.2292 per EA under NDC 65162022808. Its NADAC has been published 290 times since Feb 3, 2021.
FDA first approved this application on Sep 28, 2020. Its Orange Book therapeutic-equivalence code is AB3 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.1 mg/d
Manufacturer
Amneal Pharmaceuticals LLCNDC
65162022808
Classification
Generic
Dosage Form
PATCH, EXTENDED RELEASE
Route
TRANSDERMAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA211396FDA Approved
9/28/2020
TE Code
AB3
On Market Since
9/30/2020
Pharmacological Classes
Price Statistics
The NADAC for LYLLANA 0.1 MG PATCH has been published 290 times since Feb 3, 2021, and over the history we have for it it has held within roughly two percent of its current level. The table below summarizes its recorded NADAC range and movement.
| Current price | $8.2292 per EA |
|---|---|
| All-time high | $9.5510 (Jan 12, 2022) |
| All-time low | $5.0152 (Nov 20, 2024) |
| 52-week high | $8.2292 |
| 52-week low | $6.7754 |
| Median price | $6.8713 |
| Average price | $7.0169 |
| Largest weekly change | -24.4% (Nov 20, 2024) |
| Weeks tracked | 290 |
| Tracking since | Feb 3, 2021 |
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of LYLLANA 0.1 MG PATCH?
The current National Average Drug Acquisition Cost (NADAC) for LYLLANA 0.1 MG PATCH, manufactured by Amneal Pharmaceuticals LLC, is $8.2292 per EA (NDC 65162022808), effective Aug 19, 2026.
How has the price of LYLLANA 0.1 MG PATCH changed over time?
Over the history we have for it, the NADAC for LYLLANA 0.1 MG PATCH has held within roughly two percent of its current level. It has been tracked across 290 weekly CMS publications since Feb 3, 2021.
What are the highest and lowest recorded NADAC prices for LYLLANA 0.1 MG PATCH?
Since Feb 3, 2021, the NADAC for LYLLANA 0.1 MG PATCH has ranged from a low of $5.0152 (Nov 20, 2024) to a high of $9.5510 (Jan 12, 2022), with a median of $6.8713 per EA.
Are there cheaper alternatives to LYLLANA 0.1 MG PATCH?
4 manufacturers publish a NADAC-priced product with the same active ingredient and strength as LYLLANA 0.1 MG PATCH in a comparable dosage form, but none are currently priced below it.
Who manufactures LYLLANA 0.1 MG PATCH?
LYLLANA 0.1 MG PATCH (NDC 65162022808) is labeled by Amneal Pharmaceuticals LLC, and CMS classifies it as a generic product.