Product Information
ESTRADIOL 0.5 MG TABLET is a generic product labeled by Epic Pharma LLC, priced at $0.0608 per EA under NDC 42806008705. Its NADAC has been published 287 times since Feb 24, 2021.
FDA first approved this application on Dec 29, 1998. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/1
Manufacturer
Epic Pharma LLCNDC
42806008705
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA040275FDA Approved
12/29/1998
TE Code
AB
On Market Since
4/10/2017
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.5 MG TABLET has been published 287 times since Feb 24, 2021, and over the history we have for it it has declined 42.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0608 per EA |
|---|---|
| All-time high | $0.1072 (May 12, 2021) |
| All-time low | $0.0563 (Nov 20, 2024) |
| 52-week high | $0.0705 |
| 52-week low | $0.0583 |
| Median price | $0.0740 |
| Average price | $0.0764 |
| Largest weekly change | -26.7% (Nov 20, 2024) |
| Weeks tracked | 287 |
| Tracking since | Feb 24, 2021 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.5 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.5 MG TABLET, manufactured by Epic Pharma LLC, is $0.0608 per EA (NDC 42806008705), effective Aug 19, 2026.
How has the price of ESTRADIOL 0.5 MG TABLET changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.5 MG TABLET has declined 42.8%. It has been tracked across 287 weekly CMS publications since Feb 24, 2021.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.5 MG TABLET?
Since Feb 24, 2021, the NADAC for ESTRADIOL 0.5 MG TABLET has ranged from a low of $0.0563 (Nov 20, 2024) to a high of $0.1072 (May 12, 2021), with a median of $0.0740 per EA.
Are there cheaper alternatives to ESTRADIOL 0.5 MG TABLET?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.5 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.5 MG TABLET?
ESTRADIOL 0.5 MG TABLET (NDC 42806008705) is labeled by Epic Pharma LLC, and CMS classifies it as a generic product.