Product Information
APRISO ER 0.375 GRAM CAPSULE is a brand product labeled by Salix Pharmaceuticals Inc., priced at $4.0710 per EA under NDC 65649010302. Its NADAC has been published 606 times since Nov 28, 2013.
Strength
375 mg/1
Manufacturer
Salix Pharmaceuticals Inc.NDC
65649010302
Classification
Brand
Dosage Form
CAPSULE, EXTENDED RELEASE
Route
ORAL
Last Updated
9/17/2025
Active Ingredients
MESALAMINEApproval Type
New Drug (NDA)
FDA Application
NDA022301On Market Since
10/31/2008
Pharmacological Classes
Price Statistics
The NADAC for APRISO ER 0.375 GRAM CAPSULE has been published 606 times since Nov 28, 2013, and over the history we have for it it has risen 57.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $4.0710 per EA |
|---|---|
| All-time high | $4.2029 (Jun 17, 2015) |
| All-time low | $2.5854 (Nov 28, 2013) |
| 52-week high | $4.0728 |
| 52-week low | $4.0710 |
| Median price | $4.0751 |
| Average price | $3.7626 |
| Largest weekly change | +50.0% (Apr 8, 2015) |
| Weeks tracked | 606 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 2 NADAC-published products sharing this drug's active ingredient, strength, and dosage form across 2 manufacturers (up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 89% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of APRISO ER 0.375 GRAM CAPSULE?
The current National Average Drug Acquisition Cost (NADAC) for APRISO ER 0.375 GRAM CAPSULE, manufactured by Salix Pharmaceuticals Inc., is $4.0710 per EA (NDC 65649010302), effective Oct 1, 2025.
How has the price of APRISO ER 0.375 GRAM CAPSULE changed over time?
Over the history we have for it, the NADAC for APRISO ER 0.375 GRAM CAPSULE has risen 57.5%. It has been tracked across 606 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for APRISO ER 0.375 GRAM CAPSULE?
Since Nov 28, 2013, the NADAC for APRISO ER 0.375 GRAM CAPSULE has ranged from a low of $2.5854 (Nov 28, 2013) to a high of $4.2029 (Jun 17, 2015), with a median of $4.0751 per EA.
Are there cheaper alternatives to APRISO ER 0.375 GRAM CAPSULE?
Yes. 2 NADAC-published products share the same active ingredient, strength, and dosage form. The lowest-priced option, MESALAMINE ER 0.375 GRAM CAP, is $0.4579 per EA — about 89% below APRISO ER 0.375 GRAM CAPSULE.
Who manufactures APRISO ER 0.375 GRAM CAPSULE?
APRISO ER 0.375 GRAM CAPSULE (NDC 65649010302) is labeled by Salix Pharmaceuticals Inc., and CMS classifies it as a brand product.