Mesalamine
51 NDCs across 27 manufacturers|43 Generic,8 Brand
Mesalamine is used to treat ulcerative colitis, proctitis and sigmoid diseases, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved on Dec 24, 1987, and the first generic was approved Sep 17, 2004. FDA's Orange Book lists 37 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $312 million on Mesalamine across 651,000 claims for 155,000 beneficiaries.
Mesalamine is available as 51 NDCs from 27 manufacturers (43 generic, 8 brand), with NADAC prices from $0.46 to $134.90 per EA — the most expensive product costs about 295× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
51
43G / 8B
Manufacturers
27
competing in market
Price Spread
$0.46 – $134.90
per EA, 46 of 51 NDCs
7d Activity
avg -0.5% WoW · of 51 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Takeda Pharmaceuticals America, Inc. manufacturer profile
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Lead class
Aminosalicylate class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
Review the benchmark methodology behind the prices and spreads shown on this market page.
Manufacturer Breakdown
27 manufacturers producing MESALAMINE(3 pricing outliers)
Frequently Asked Questions
What is Mesalamine used to treat?
Mesalamine is used to treat ulcerative colitis, proctitis and sigmoid diseases, per the National Library of Medicine's MED-RT classification.
When did Mesalamine become available as a generic?
FDA approved the first generic Mesalamine (ANDA) on Sep 17, 2004. The Orange Book currently lists 37 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Mesalamine?
In 2024, Medicare Part D spent $312 million on Mesalamine across 651,000 claims for 155,000 beneficiaries.
How many Mesalamine products are on the market?
The Mesalamine drug market contains 51 NDCs from 27 manufacturers — 43 generic and 8 brand products.
What is the price range for Mesalamine?
NADAC reference prices for Mesalamine range from $0.4579 to $134.9044 per EA — the most expensive product costs about 295× the cheapest. 5 additional products are priced per different units (e.g. liquids per ML) and aren't directly comparable.
Is generic Mesalamine cheaper than brand?
The average generic NADAC for Mesalamine is $8.4091 per EA, versus $14.2299 for brand-labeled products — generic is about 41% cheaper on average.
Which manufacturers make Mesalamine?
27 manufacturers list Mesalamine in NADAC. Ranked by number of NDCs, the largest are Takeda Pharmaceuticals America, Inc. (6), Padagis Israel Pharmaceuticals Ltd (4), American Health Packaging (4), Zydus Pharmaceuticals (USA) Inc. (4), Teva Pharmaceuticals USA Inc. (3).
How has the price of Mesalamine changed recently?
Over the past 7 days, 11 Mesalamine NDCs rose and 34 fell, with a market-wide average change of -0.5%.