Product Information
SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB is a generic product labeled by Prasco Laboratories, priced at $0.4833 per EA under NDC 66993018802. Its NADAC has been published 243 times since Feb 9, 2022.
FDA first approved this application on Dec 30, 1982. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25; 25 mg/1; mg/1
Manufacturer
Prasco LaboratoriesNDC
66993018802
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
HYDROCHLOROTHIAZIDE; SPIRONOLACTONEApproval Type
Authorized Generic (NDA)
FDA Application
NDA012616FDA Approved
12/30/1982
TE Code
AB
On Market Since
11/29/2021
Pharmacological Classes
Price Statistics
The NADAC for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB has been published 243 times since Feb 9, 2022, and over the history we have for it it has declined 20.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.4833 per EA |
|---|---|
| All-time high | $0.6867 (May 11, 2022) |
| All-time low | $0.3906 (Nov 20, 2024) |
| 52-week high | $0.5620 |
| 52-week low | $0.4833 |
| Median price | $0.5809 |
| Average price | $0.5783 |
| Largest weekly change | +37.7% (Aug 21, 2024) |
| Weeks tracked | 243 |
| Tracking since | Feb 9, 2022 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Prasco Laboratories manufacturer profile
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Drug market
spironolactone and hydrochlorothiazide market comparison
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Therapeutic class
Aldosterone Antagonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB?
The current National Average Drug Acquisition Cost (NADAC) for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB, manufactured by Prasco Laboratories, is $0.4833 per EA (NDC 66993018802), effective Sep 30, 2026.
How has the price of SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB changed over time?
Over the history we have for it, the NADAC for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB has declined 20.5%. It has been tracked across 243 weekly CMS publications since Feb 9, 2022.
What are the highest and lowest recorded NADAC prices for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB?
Since Feb 9, 2022, the NADAC for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB has ranged from a low of $0.3906 (Nov 20, 2024) to a high of $0.6867 (May 11, 2022), with a median of $0.5809 per EA.
Are there cheaper alternatives to SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB in a comparable dosage form, but none are currently priced below it.
Who manufactures SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB?
SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB (NDC 66993018802) is labeled by Prasco Laboratories, and CMS classifies it as a generic product.