Product Information
MEMANTINE HCL ER 21 MG CAPSULE is a generic product labeled by Lupin Pharmaceuticals Inc., priced at $0.3563 per EA under NDC 68180024806. Its NADAC has been published 437 times since May 23, 2018.
FDA first approved this application on Sep 28, 2016. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
21 mg/1
Manufacturer
Lupin Pharmaceuticals Inc.NDC
68180024806
Classification
Generic
Dosage Form
CAPSULE, EXTENDED RELEASE
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
MEMANTINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA206028FDA Approved
9/28/2016
TE Code
AB
On Market Since
2/20/2018
Pharmacological Classes
Price Statistics
The NADAC for MEMANTINE HCL ER 21 MG CAPSULE has been published 437 times since May 23, 2018, and over the history we have for it it has declined 93.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.3563 per EA |
|---|---|
| All-time high | $6.8777 (Jul 11, 2018) |
| All-time low | $0.3021 (Dec 17, 2025) |
| 52-week high | $0.3820 |
| 52-week low | $0.3021 |
| Median price | $0.9110 |
| Average price | $1.5442 |
| Largest weekly change | +71.8% (Oct 19, 2022) |
| Weeks tracked | 437 |
| Tracking since | May 23, 2018 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Lupin Pharmaceuticals Inc. manufacturer profile
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Drug market
memantine hydrochloride market comparison
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Therapeutic class
N-methyl-D-aspartate Receptor Antagonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of MEMANTINE HCL ER 21 MG CAPSULE?
The current National Average Drug Acquisition Cost (NADAC) for MEMANTINE HCL ER 21 MG CAPSULE, manufactured by Lupin Pharmaceuticals Inc., is $0.3563 per EA (NDC 68180024806), effective Sep 30, 2026.
How has the price of MEMANTINE HCL ER 21 MG CAPSULE changed over time?
Over the history we have for it, the NADAC for MEMANTINE HCL ER 21 MG CAPSULE has declined 93.9%. It has been tracked across 437 weekly CMS publications since May 23, 2018.
What are the highest and lowest recorded NADAC prices for MEMANTINE HCL ER 21 MG CAPSULE?
Since May 23, 2018, the NADAC for MEMANTINE HCL ER 21 MG CAPSULE has ranged from a low of $0.3021 (Dec 17, 2025) to a high of $6.8777 (Jul 11, 2018), with a median of $0.9110 per EA.
Are there cheaper alternatives to MEMANTINE HCL ER 21 MG CAPSULE?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as MEMANTINE HCL ER 21 MG CAPSULE in a comparable dosage form, but none are currently priced below it.
Who manufactures MEMANTINE HCL ER 21 MG CAPSULE?
MEMANTINE HCL ER 21 MG CAPSULE (NDC 68180024806) is labeled by Lupin Pharmaceuticals Inc., and CMS classifies it as a generic product.