This NDC is on FDA's drug shortage list (posted Dec 15, 2021)
Reported reason: Other
Product Information
METHYLPREDNISOLONE 40 MG/ML VL is a generic product labeled by Amneal Pharmaceuticals LLC, priced at $8.1220 per ML under NDC 70121157301. Its NADAC has been published 144 times since Mar 23, 2022.
FDA first approved this application on May 20, 2019. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
40 mg/mL
Manufacturer
Amneal Pharmaceuticals LLCNDC
70121157301
Classification
Generic
Dosage Form
INJECTION, SUSPENSION
Route
INTRA-ARTICULAR; INTRALESIONAL; INTRAMUSCULAR; INTRASYNOVIAL; SOFT TISSUE
Effective Date
12/17/2025
Active Ingredients
METHYLPREDNISOLONE ACETATEApproval Type
Generic (ANDA)
FDA Application
ANDA210043FDA Approved
5/20/2019
TE Code
AB
On Market Since
5/20/2019
Pharmacological Classes
Price Statistics
The NADAC for METHYLPREDNISOLONE 40 MG/ML VL has been published 144 times since Mar 23, 2022, and over the history we have for it it has declined 6.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $8.1220 per ML |
|---|---|
| All-time high | $8.6967 (Mar 15, 2023) |
| All-time low | $8.1220 (Oct 22, 2025) |
| 52-week high | $8.3017 |
| 52-week low | $8.1220 |
| Median price | $8.3017 |
| Average price | $8.3943 |
| Largest weekly change | -4.6% (Nov 20, 2024) |
| Weeks tracked | 144 |
| Tracking since | Mar 23, 2022 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 28% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of METHYLPREDNISOLONE 40 MG/ML VL?
The current National Average Drug Acquisition Cost (NADAC) for METHYLPREDNISOLONE 40 MG/ML VL, manufactured by Amneal Pharmaceuticals LLC, is $8.1220 per ML (NDC 70121157301), effective Aug 19, 2026.
How has the price of METHYLPREDNISOLONE 40 MG/ML VL changed over time?
Over the history we have for it, the NADAC for METHYLPREDNISOLONE 40 MG/ML VL has declined 6.6%. It has been tracked across 144 weekly CMS publications since Mar 23, 2022.
What are the highest and lowest recorded NADAC prices for METHYLPREDNISOLONE 40 MG/ML VL?
Since Mar 23, 2022, the NADAC for METHYLPREDNISOLONE 40 MG/ML VL has ranged from a low of $8.1220 (Oct 22, 2025) to a high of $8.6967 (Mar 15, 2023), with a median of $8.3017 per ML.
Are there cheaper alternatives to METHYLPREDNISOLONE 40 MG/ML VL?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, METHYLPREDNISOLONE 400 MG/10 ML, is $5.8078 per ML — about 28% below METHYLPREDNISOLONE 40 MG/ML VL.
Who manufactures METHYLPREDNISOLONE 40 MG/ML VL?
METHYLPREDNISOLONE 40 MG/ML VL (NDC 70121157301) is labeled by Amneal Pharmaceuticals LLC, and CMS classifies it as a generic product.
Is METHYLPREDNISOLONE 40 MG/ML VL in shortage?
Yes — NDC 70121157301 is currently listed in FDA's drug shortage database (posted Dec 15, 2021). Reported reason: Other.