Product Information
METHYLPREDNISOLONE 400 MG/5 ML is a generic product labeled by Amneal Pharmaceuticals LLC, priced at $13.0533 per ML under NDC 70121161001. Its NADAC has been published 87 times since Sep 18, 2024.
FDA first approved this application on Nov 3, 2023. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The High Outlier badge above means this manufacturer's average price in the Methylprednisolone acetate market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
80 mg/mL
Manufacturer
Amneal Pharmaceuticals LLCNDC
70121161001
Classification
Generic
Dosage Form
INJECTION, SUSPENSION
Route
INTRA-ARTICULAR; INTRALESIONAL; INTRAMUSCULAR; INTRASYNOVIAL; SOFT TISSUE
Effective Date
5/21/2025
Active Ingredients
METHYLPREDNISOLONE ACETATEApproval Type
Generic (ANDA)
FDA Application
ANDA216502FDA Approved
11/3/2023
TE Code
AB
On Market Since
11/10/2023
Pharmacological Classes
Price Statistics
The NADAC for METHYLPREDNISOLONE 400 MG/5 ML has been published 87 times since Sep 18, 2024, and over the history we have for it it has declined 12.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $13.0533 per ML |
|---|---|
| All-time high | $14.9732 (Oct 16, 2024) |
| All-time low | $13.0533 (May 21, 2025) |
| 52-week high | $13.0533 |
| 52-week low | $13.0533 |
| Median price | $13.0533 |
| Average price | $13.4333 |
| Largest weekly change | -5.1% (Oct 23, 2024) |
| Weeks tracked | 87 |
| Tracking since | Sep 18, 2024 |
1W
N/A
1M
N/A
3M
N/A
6M
0.0%
1Y
0.0%
3Y
N/A
5Y
N/A
All
-12.8%
Last surveyed May 13, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 9% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Amneal Pharmaceuticals LLC manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Methylprednisolone acetate market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Corticosteroid class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of METHYLPREDNISOLONE 400 MG/5 ML?
The current National Average Drug Acquisition Cost (NADAC) for METHYLPREDNISOLONE 400 MG/5 ML, manufactured by Amneal Pharmaceuticals LLC, is $13.0533 per ML (NDC 70121161001), effective May 13, 2026.
How has the price of METHYLPREDNISOLONE 400 MG/5 ML changed over time?
Over the history we have for it, the NADAC for METHYLPREDNISOLONE 400 MG/5 ML has declined 12.8%. It has been tracked across 87 weekly CMS publications since Sep 18, 2024.
What are the highest and lowest recorded NADAC prices for METHYLPREDNISOLONE 400 MG/5 ML?
Since Sep 18, 2024, the NADAC for METHYLPREDNISOLONE 400 MG/5 ML has ranged from a low of $13.0533 (May 21, 2025) to a high of $14.9732 (Oct 16, 2024), with a median of $13.0533 per ML.
Are there cheaper alternatives to METHYLPREDNISOLONE 400 MG/5 ML?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, METHYLPREDNISOLONE 80 MG/ML VL, is $11.9243 per ML — about 9% below METHYLPREDNISOLONE 400 MG/5 ML.
Who manufactures METHYLPREDNISOLONE 400 MG/5 ML?
METHYLPREDNISOLONE 400 MG/5 ML (NDC 70121161001) is labeled by Amneal Pharmaceuticals LLC, and CMS classifies it as a generic product.