This NDC is on FDA's drug shortage list (posted Feb 20, 2018)
Reported reason: Discontinuation of the manufacture of the drug
Product Information
BUPIVACAINE 0.25% VIAL is a generic product labeled by Meitheal Pharmaceuticals Inc., priced at $0.0479 per ML under NDC 71288072352. Its NADAC has been published 44 times since Oct 22, 2025.
FDA first approved this application on Jun 23, 2023. Its Orange Book therapeutic-equivalence code is AP.
Strength
2.5 mg/mL
Manufacturer
Meitheal Pharmaceuticals Inc.NDC
71288072352
Classification
Generic
Dosage Form
INJECTION, SOLUTION
Route
INFILTRATION; PERINEURAL
Effective Date
5/20/2026
Active Ingredients
BUPIVACAINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA216039FDA Approved
6/23/2023
TE Code
AP
On Market Since
6/23/2023
Pharmacological Classes
Price Statistics
The NADAC for BUPIVACAINE 0.25% VIAL has been published 44 times since Oct 22, 2025, and over the history we have for it it has risen 3.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0479 per ML |
|---|---|
| All-time high | $0.0479 (Aug 19, 2026) |
| All-time low | $0.0453 (Nov 19, 2025) |
| 52-week high | $0.0479 |
| 52-week low | $0.0453 |
| Median price | $0.0479 |
| Average price | $0.0471 |
| Largest weekly change | +2.6% (Feb 18, 2026) |
| Weeks tracked | 44 |
| Tracking since | Oct 22, 2025 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the bupivacaine hydrochloride market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of BUPIVACAINE 0.25% VIAL?
The current National Average Drug Acquisition Cost (NADAC) for BUPIVACAINE 0.25% VIAL, manufactured by Meitheal Pharmaceuticals Inc., is $0.0479 per ML (NDC 71288072352), effective Aug 19, 2026.
How has the price of BUPIVACAINE 0.25% VIAL changed over time?
Over the history we have for it, the NADAC for BUPIVACAINE 0.25% VIAL has risen 3.4%. It has been tracked across 44 weekly CMS publications since Oct 22, 2025.
What are the highest and lowest recorded NADAC prices for BUPIVACAINE 0.25% VIAL?
Since Oct 22, 2025, the NADAC for BUPIVACAINE 0.25% VIAL has ranged from a low of $0.0453 (Nov 19, 2025) to a high of $0.0479 (Aug 19, 2026), with a median of $0.0479 per ML.
Are there cheaper alternatives to BUPIVACAINE 0.25% VIAL?
No other NADAC-published product currently shares the active ingredient and strength of BUPIVACAINE 0.25% VIAL in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures BUPIVACAINE 0.25% VIAL?
BUPIVACAINE 0.25% VIAL (NDC 71288072352) is labeled by Meitheal Pharmaceuticals Inc., and CMS classifies it as a generic product.
Is BUPIVACAINE 0.25% VIAL in shortage?
Yes — NDC 71288072352 is currently listed in FDA's drug shortage database (posted Feb 20, 2018). Reported reason: Discontinuation of the manufacture of the drug.