Product Information
RHOFADE 1% CREAM is a brand product labeled by EPI Health, LLC, priced at $22.5013 per GM under NDC 71403000330. Its NADAC has been published 232 times since May 19, 2021.
FDA first approved this application on Jan 18, 2017. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The High Outlier badge above means this manufacturer's average price in the OXYMETAZOLINE HYDROCHLORIDE market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
1 g/100g
Manufacturer
EPI Health, LLCNDC
71403000330
Classification
Brand
Dosage Form
CREAM
Route
TOPICAL
Effective Date
10/22/2025
Active Ingredients
OXYMETAZOLINE HYDROCHLORIDEApproval Type
New Drug (NDA)
FDA Application
NDA208552FDA Approved
1/18/2017
TE Code
AB
On Market Since
1/18/2021
Pharmacological Classes
Price Statistics
The NADAC for RHOFADE 1% CREAM has been published 232 times since May 19, 2021, and over the history we have for it it has risen 29.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $22.5013 per GM |
|---|---|
| All-time high | $23.4846 (Jul 16, 2025) |
| All-time low | $17.3326 (May 19, 2021) |
| 52-week high | $22.5013 |
| 52-week low | $22.1796 |
| Median price | $18.2565 |
| Average price | $19.5297 |
| Largest weekly change | +9.0% (Feb 12, 2025) |
| Weeks tracked | 232 |
| Tracking since | May 19, 2021 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
+1.5%
3Y
+24.3%
5Y
+29.8%
All
+29.8%
Last surveyed Oct 22, 2025 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the OXYMETAZOLINE HYDROCHLORIDE market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of RHOFADE 1% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for RHOFADE 1% CREAM, manufactured by EPI Health, LLC, is $22.5013 per GM (NDC 71403000330), effective Oct 22, 2025.
How has the price of RHOFADE 1% CREAM changed over time?
Over the history we have for it, the NADAC for RHOFADE 1% CREAM has risen 29.8%. It has been tracked across 232 weekly CMS publications since May 19, 2021.
What are the highest and lowest recorded NADAC prices for RHOFADE 1% CREAM?
Since May 19, 2021, the NADAC for RHOFADE 1% CREAM has ranged from a low of $17.3326 (May 19, 2021) to a high of $23.4846 (Jul 16, 2025), with a median of $18.2565 per GM.
Are there cheaper alternatives to RHOFADE 1% CREAM?
No other NADAC-published product currently shares the active ingredient and strength of RHOFADE 1% CREAM in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures RHOFADE 1% CREAM?
RHOFADE 1% CREAM (NDC 71403000330) is labeled by EPI Health, LLC, and CMS classifies it as a brand product.